Persistent Link:
http://hdl.handle.net/10150/277190
Title:
Crystallization kinetics of diphenylhydantoin
Author:
Yang, Li-yin, 1952-
Issue Date:
1989
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The crystallization kinetics of diphenylhydantoin (DPH) has been studied at constant conditions in a small mixed suspension mixed product removal (MSMPR) crystallizer. Supersaturation is created by changing the pH of a DPH solution in the crystallization vessel. Crystal size distributions (CSD's) are measured by an in situ zone sensing method. Effects of pH and supersaturation on crystallization kinetics and CSD are summarized. The effect of an additive on the crystal growth of DPH has been studied in a batch system. Avoidance of nucleation in the early stages of crystallization is essential to the effect investigated.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Phenytoin.; Crystallization.; Crystal growth.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Pharmaceutical Sciences
Degree Grantor:
University of Arizona
Advisor:
Rodriquez, Nair

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleCrystallization kinetics of diphenylhydantoinen_US
dc.creatorYang, Li-yin, 1952-en_US
dc.contributor.authorYang, Li-yin, 1952-en_US
dc.date.issued1989en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe crystallization kinetics of diphenylhydantoin (DPH) has been studied at constant conditions in a small mixed suspension mixed product removal (MSMPR) crystallizer. Supersaturation is created by changing the pH of a DPH solution in the crystallization vessel. Crystal size distributions (CSD's) are measured by an in situ zone sensing method. Effects of pH and supersaturation on crystallization kinetics and CSD are summarized. The effect of an additive on the crystal growth of DPH has been studied in a batch system. Avoidance of nucleation in the early stages of crystallization is essential to the effect investigated.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectPhenytoin.en_US
dc.subjectCrystallization.en_US
dc.subjectCrystal growth.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePharmaceutical Sciencesen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorRodriquez, Nairen_US
dc.identifier.proquest1339072en_US
dc.identifier.oclc23259053en_US
dc.identifier.bibrecord.b17606998en_US
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