Persistent Link:
http://hdl.handle.net/10150/277186
Title:
Effect of pH on the structure and function of La Crosse virus
Author:
Wang, Guo-Ji, 1953-
Issue Date:
1989
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The La Crosse (LAC) virus is a member of the California encephalitis group of bunyaviridae (Porterfield et al., 1975 and 1976). It is one of an envelope virus and this virus under acidic conditions (below pH 6.3) has been demonstrated to result in cell-to-cell fusion (Gonzalez-Scarano, 1984). The LAC virus is also capable of forming virus-to-virus fusion particles. The focus of this thesis is the analysis of the structure and function of this virus-to-virus fusion by cryo-electron microscopy at different pH and temperatures. The results of this study provide the basis for further study of the structure and function of the LAC virus. The virus-to-virus fusion event shows a dependence on both pH and temperature. The frequency of the fusion event increases with an elevation in temperature (in the range 4 to 37°C) and with a decrease in pH from 7.3 to 5.4. The process of virus-to-virus fusion gives rise to the formation budding to a chain of fused viruses.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Bunyaviruses.; Viruses -- Morphology.; Hydrogen-ion concentration.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Molecular and Cellular Biology
Degree Grantor:
University of Arizona
Advisor:
Hewlett, Martinez J.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleEffect of pH on the structure and function of La Crosse virusen_US
dc.creatorWang, Guo-Ji, 1953-en_US
dc.contributor.authorWang, Guo-Ji, 1953-en_US
dc.date.issued1989en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe La Crosse (LAC) virus is a member of the California encephalitis group of bunyaviridae (Porterfield et al., 1975 and 1976). It is one of an envelope virus and this virus under acidic conditions (below pH 6.3) has been demonstrated to result in cell-to-cell fusion (Gonzalez-Scarano, 1984). The LAC virus is also capable of forming virus-to-virus fusion particles. The focus of this thesis is the analysis of the structure and function of this virus-to-virus fusion by cryo-electron microscopy at different pH and temperatures. The results of this study provide the basis for further study of the structure and function of the LAC virus. The virus-to-virus fusion event shows a dependence on both pH and temperature. The frequency of the fusion event increases with an elevation in temperature (in the range 4 to 37°C) and with a decrease in pH from 7.3 to 5.4. The process of virus-to-virus fusion gives rise to the formation budding to a chain of fused viruses.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectBunyaviruses.en_US
dc.subjectViruses -- Morphology.en_US
dc.subjectHydrogen-ion concentration.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineMolecular and Cellular Biologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorHewlett, Martinez J.en_US
dc.identifier.proquest1339067en_US
dc.identifier.oclc23264948en_US
dc.identifier.bibrecord.b17607632en_US
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