Influence of copper deficiency on plasma lipoproteins and the development of enlarged plasma volume and cholesterol pool size

Persistent Link:
http://hdl.handle.net/10150/277117
Title:
Influence of copper deficiency on plasma lipoproteins and the development of enlarged plasma volume and cholesterol pool size
Author:
Al-Othman, Abdullah Abdulrahman, 1961-
Issue Date:
1989
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Two studies were designed to investigate the time course development of enlarged plasma volume and cholesterol pool size in copper (Cu)-deficient rats as well as influence of Cu deficiency on the lipid composition of lipoproteins. Rats were randomly assigned to three dietary Cu treatments (deficient, marginal, and adequate) in the Study I and two dietary Cu treatments (deficient and adequate) in Study II. Enlargement of plasma volume and cholesterol pool size were established prior to the increase in plasma cholesterol concentration. Cu concentration was decreased, whereas iron and zinc concentrations were increased in the organs of Cu-deficient and Cu-marginal rats. The plasma pool size of VLDL triglyceride was elevated 6-fold, protein and phospholipid were unaltered, and cholesterol was reduced 36%. The plasma pool size of lipid and protein components of HDL and LDL fractions were markedly elevated in Cu-deficient rats.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Copper in animal nutrition.; Blood lipoproteins.; Cholesterol -- Bioaccumulation.; Blood plasma.; Hypocupremia -- Complications.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Nutritional Sciences
Degree Grantor:
University of Arizona
Advisor:
Lei, K. Y.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleInfluence of copper deficiency on plasma lipoproteins and the development of enlarged plasma volume and cholesterol pool sizeen_US
dc.creatorAl-Othman, Abdullah Abdulrahman, 1961-en_US
dc.contributor.authorAl-Othman, Abdullah Abdulrahman, 1961-en_US
dc.date.issued1989en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractTwo studies were designed to investigate the time course development of enlarged plasma volume and cholesterol pool size in copper (Cu)-deficient rats as well as influence of Cu deficiency on the lipid composition of lipoproteins. Rats were randomly assigned to three dietary Cu treatments (deficient, marginal, and adequate) in the Study I and two dietary Cu treatments (deficient and adequate) in Study II. Enlargement of plasma volume and cholesterol pool size were established prior to the increase in plasma cholesterol concentration. Cu concentration was decreased, whereas iron and zinc concentrations were increased in the organs of Cu-deficient and Cu-marginal rats. The plasma pool size of VLDL triglyceride was elevated 6-fold, protein and phospholipid were unaltered, and cholesterol was reduced 36%. The plasma pool size of lipid and protein components of HDL and LDL fractions were markedly elevated in Cu-deficient rats.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectCopper in animal nutrition.en_US
dc.subjectBlood lipoproteins.en_US
dc.subjectCholesterol -- Bioaccumulation.en_US
dc.subjectBlood plasma.en_US
dc.subjectHypocupremia -- Complications.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineNutritional Sciencesen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorLei, K. Y.en_US
dc.identifier.proquest1338080en_US
dc.identifier.oclc23156843en_US
dc.identifier.bibrecord.b17583317en_US
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