Longitudinal changes in cellular immunity in the first year of life and lack of relationship to serum immunoglobulin-E

Persistent Link:
http://hdl.handle.net/10150/277018
Title:
Longitudinal changes in cellular immunity in the first year of life and lack of relationship to serum immunoglobulin-E
Author:
Stern, Debra Ann, 1958-
Issue Date:
1989
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The present study was undertaken to explore the relationship of cellular immunity to total serum ICE in an unselected sample of 278 healthy infants. Statistical analyses of infant history profiles and cellular immune and serum IgE determinations from cord blood and 10 month samples were performed using SPSSx. During the first year of life, the percent CD3, CD4, CD8, ERFC, and B-cell counts significantly increased and the CD4/CD8 ratio and responses to ConA and PW mitogens significantly decreased. Boys had lower percent CD8 cell counts and decreased responses to ConA and PW mitogens in cord blood. Cellular immune variable values were not associated with total serum ICE in any analysis. Early feeding method had no effect on 10 month serum IgE levels or cellular immune variables. Cord blood percent CD3 and CD4 cell counts were significantly decreased in infants with parental histories of asthma. In summary, (1) boys had a lower percent of suppressor T-cells and lower mitogen responses in cord blood (2) boys and girls reached similar levels for all variables by 10 months of age (3) infants with familial histories of asthma had fewer total and helper T-cells in cord blood.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Cellular immunity -- Longitudinal studies.; Immunoglobulin E.; Infants -- Nutrition -- Immunological aspects.; Newborn infants -- Immunology.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Microbiology and Immunology
Degree Grantor:
University of Arizona
Advisor:
Pinnas, Jacob

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleLongitudinal changes in cellular immunity in the first year of life and lack of relationship to serum immunoglobulin-Een_US
dc.creatorStern, Debra Ann, 1958-en_US
dc.contributor.authorStern, Debra Ann, 1958-en_US
dc.date.issued1989en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe present study was undertaken to explore the relationship of cellular immunity to total serum ICE in an unselected sample of 278 healthy infants. Statistical analyses of infant history profiles and cellular immune and serum IgE determinations from cord blood and 10 month samples were performed using SPSSx. During the first year of life, the percent CD3, CD4, CD8, ERFC, and B-cell counts significantly increased and the CD4/CD8 ratio and responses to ConA and PW mitogens significantly decreased. Boys had lower percent CD8 cell counts and decreased responses to ConA and PW mitogens in cord blood. Cellular immune variable values were not associated with total serum ICE in any analysis. Early feeding method had no effect on 10 month serum IgE levels or cellular immune variables. Cord blood percent CD3 and CD4 cell counts were significantly decreased in infants with parental histories of asthma. In summary, (1) boys had a lower percent of suppressor T-cells and lower mitogen responses in cord blood (2) boys and girls reached similar levels for all variables by 10 months of age (3) infants with familial histories of asthma had fewer total and helper T-cells in cord blood.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectCellular immunity -- Longitudinal studies.en_US
dc.subjectImmunoglobulin E.en_US
dc.subjectInfants -- Nutrition -- Immunological aspects.en_US
dc.subjectNewborn infants -- Immunology.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineMicrobiology and Immunologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorPinnas, Jacoben_US
dc.identifier.proquest1336907en_US
dc.identifier.oclc22895121en_US
dc.identifier.bibrecord.b17525044en_US
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