The influence of copper deficiency on the binding and uptake of high-density lipoprotein by rat hepatic parenchymal cells

Persistent Link:
http://hdl.handle.net/10150/276935
Title:
The influence of copper deficiency on the binding and uptake of high-density lipoprotein by rat hepatic parenchymal cells
Author:
Zhang, Jin, 1960-
Issue Date:
1988
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
This study was designed to examine the influence of Cu deficiency on the binding, uptake, and degradation of apolipoprotein E-free high density lipoproteins (apo E-free HDL) in cultured rat hepatic parenchymal cells. The binding of apo E-free HDL during time course studies was slightly but significantly increased in cells derived from Cu-deficient rats. In saturation studies, the amount of surface-bound apo E-free HDL appeared to be saturable, although no difference was observed between Cu-deficient and adequate animals. The amount of total and specific cell-associated uptake of apo E-free HDL was significantly increased in hepatic parenchymal cells of Cu-deficient animals. The present data suggest that hepatic uptake of the HDL protein moiety may be increased in rats fed a diet deficient in copper.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Copper -- Physiological effect.; Trace elements in the body.; Liver cells.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Nutritional Sciences
Degree Grantor:
University of Arizona
Advisor:
Lei, David K. Y.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleThe influence of copper deficiency on the binding and uptake of high-density lipoprotein by rat hepatic parenchymal cellsen_US
dc.creatorZhang, Jin, 1960-en_US
dc.contributor.authorZhang, Jin, 1960-en_US
dc.date.issued1988en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThis study was designed to examine the influence of Cu deficiency on the binding, uptake, and degradation of apolipoprotein E-free high density lipoproteins (apo E-free HDL) in cultured rat hepatic parenchymal cells. The binding of apo E-free HDL during time course studies was slightly but significantly increased in cells derived from Cu-deficient rats. In saturation studies, the amount of surface-bound apo E-free HDL appeared to be saturable, although no difference was observed between Cu-deficient and adequate animals. The amount of total and specific cell-associated uptake of apo E-free HDL was significantly increased in hepatic parenchymal cells of Cu-deficient animals. The present data suggest that hepatic uptake of the HDL protein moiety may be increased in rats fed a diet deficient in copper.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectCopper -- Physiological effect.en_US
dc.subjectTrace elements in the body.en_US
dc.subjectLiver cells.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineNutritional Sciencesen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorLei, David K. Y.en_US
dc.identifier.proquest1335863en_US
dc.identifier.oclc22684813en_US
dc.identifier.bibrecord.b18418454en_US
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