The pulmonary inflammatory and fibrotic response induced by glass fibers

Persistent Link:
http://hdl.handle.net/10150/276624
Title:
The pulmonary inflammatory and fibrotic response induced by glass fibers
Author:
Pustilnik, Leslie Royce, 1964-
Issue Date:
1987
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The present study was initiated to evaluate the pulmonary inflammatory and fibrotic responses induced by single and repeated exposures to glass fibers. Single and repeated intratracheal injections of glass fibers induced an acute inflammatory response which progressed to a chronic inflammatory and fibrotic response. Mice exposed to glass fibers in single or repeated doses demonstrated elevated numbers of eosinophils, neutrophils and macrophages and increases in cell-free protein in lung lavage fluid at five days post-exposure. These parameters, in addition to relative lung/body weight ratios and lung tissue hydroxyproline levels, were elevated in comparison to saline control animals at five weeks post-exposure. Although repeated exposures to glass fibers did not potentiate the cellular inflammatory response, they did induce a marked infiltration of eosinophils, a response not observed with either asbestos or silica exposures. These observations suggest that glass fibers may be more toxic to the lungs than previously thought.
Type:
text; Thesis-Reproduction (electronic)
Keywords:
Glass fibers -- Physiological effect.; Silicate fibers -- Physiological effect.; Lungs -- Diseases.; Pulmonary fibrosis.
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Pharmacology and Toxicology
Degree Grantor:
University of Arizona
Advisor:
Hubbard, Andrea K.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_US
dc.titleThe pulmonary inflammatory and fibrotic response induced by glass fibersen_US
dc.creatorPustilnik, Leslie Royce, 1964-en_US
dc.contributor.authorPustilnik, Leslie Royce, 1964-en_US
dc.date.issued1987en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe present study was initiated to evaluate the pulmonary inflammatory and fibrotic responses induced by single and repeated exposures to glass fibers. Single and repeated intratracheal injections of glass fibers induced an acute inflammatory response which progressed to a chronic inflammatory and fibrotic response. Mice exposed to glass fibers in single or repeated doses demonstrated elevated numbers of eosinophils, neutrophils and macrophages and increases in cell-free protein in lung lavage fluid at five days post-exposure. These parameters, in addition to relative lung/body weight ratios and lung tissue hydroxyproline levels, were elevated in comparison to saline control animals at five weeks post-exposure. Although repeated exposures to glass fibers did not potentiate the cellular inflammatory response, they did induce a marked infiltration of eosinophils, a response not observed with either asbestos or silica exposures. These observations suggest that glass fibers may be more toxic to the lungs than previously thought.en_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
dc.subjectGlass fibers -- Physiological effect.en_US
dc.subjectSilicate fibers -- Physiological effect.en_US
dc.subjectLungs -- Diseases.en_US
dc.subjectPulmonary fibrosis.en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePharmacology and Toxicologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorHubbard, Andrea K.en_US
dc.identifier.proquest1332537en_US
dc.identifier.oclc20061315en_US
dc.identifier.bibrecord.b16916554en_US
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