Perceptual Mnemonic Medial Temporal Lobe Function in Individuals with Down Syndrome

Persistent Link:
http://hdl.handle.net/10150/255154
Title:
Perceptual Mnemonic Medial Temporal Lobe Function in Individuals with Down Syndrome
Author:
Spanò, Goffredina
Issue Date:
2012
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Behavioral data in individuals with Down syndrome (DS) and mouse models of the syndrome suggest impaired object processing. In this study we examined the component processes that may contribute to object memory deficits. A neuropsychological test battery was administered to individuals with DS (n=28), including tests targeting perirhinal cortex (PRC) and prefrontal cortex (PFC) function, tests of perception (i.e., convexity based figure ground perception), and tests of memory (object recognition and object-in-place learning). To compare to individuals with DS, the same number of typically developing chronological age (CA, n=28) and mental age-matched (MA, n=28) controls were recruited. We observed object memory deficits in DS (p<0.001). In contrast, the DS group showed relatively intact use of convexity when making figure-ground judgments and spared PRC-dependent function, as compared to MA control. In addition, measures of PFC function seemed to be related to performance on object recognition tasks. These findings suggest that the inputs into the MTL from low and high level perceptual processing streams may be intact in DS. The object memory deficits we observed might reflect impaired PFC function.
Type:
text; Electronic Thesis
Keywords:
perirhinal cortex; prefrontal cortex; visual perception; Psychology; Down syndrome; object recognition
Degree Name:
M.A.
Degree Level:
masters
Degree Program:
Graduate College; Psychology
Degree Grantor:
University of Arizona
Advisor:
Edgin, Jamie Ogline

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titlePerceptual Mnemonic Medial Temporal Lobe Function in Individuals with Down Syndromeen_US
dc.creatorSpanò, Goffredinaen_US
dc.contributor.authorSpanò, Goffredinaen_US
dc.date.issued2012-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractBehavioral data in individuals with Down syndrome (DS) and mouse models of the syndrome suggest impaired object processing. In this study we examined the component processes that may contribute to object memory deficits. A neuropsychological test battery was administered to individuals with DS (n=28), including tests targeting perirhinal cortex (PRC) and prefrontal cortex (PFC) function, tests of perception (i.e., convexity based figure ground perception), and tests of memory (object recognition and object-in-place learning). To compare to individuals with DS, the same number of typically developing chronological age (CA, n=28) and mental age-matched (MA, n=28) controls were recruited. We observed object memory deficits in DS (p<0.001). In contrast, the DS group showed relatively intact use of convexity when making figure-ground judgments and spared PRC-dependent function, as compared to MA control. In addition, measures of PFC function seemed to be related to performance on object recognition tasks. These findings suggest that the inputs into the MTL from low and high level perceptual processing streams may be intact in DS. The object memory deficits we observed might reflect impaired PFC function.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
dc.subjectperirhinal cortexen_US
dc.subjectprefrontal cortexen_US
dc.subjectvisual perceptionen_US
dc.subjectPsychologyen_US
dc.subjectDown syndromeen_US
dc.subjectobject recognitionen_US
thesis.degree.nameM.A.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePsychologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorEdgin, Jamie Oglineen_US
dc.contributor.committeememberNadel, Lynnen_US
dc.contributor.committeememberPeterson, Mary A.en_US
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