Persistent Link:
http://hdl.handle.net/10150/244788
Title:
Matrix Degradation and Invasion in Breast Cancer
Author:
Starobinska, Ella
Issue Date:
May-2012
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
In order to metastasize, cancer cells need to invade and degrade matrix. Previous research showed that Epidermal Growth Factor Receptor (EGFR) is an oncogene, a member of ErBb family, that is over-expressed in aggressive cancers. EGFR mediates cell survival, proliferation, and motility through different signaling pathways. Located on the basolateral membrane of the cell, EGFR can be either translocated to the nucleus, degraded by the lysosome or recycled. However, in cancerous cells, EGFR activity is altered by MUC1, which associates itself with EGFR. Research suggested that this pathway acts in a Met-dependent manner. We conducted matrix degradation and invasion assays to see whether MUC1/EGFR activity has affect on these processes. Matrix degradation assay showed that Muc1 and EGFR inhibit matrix degradation and PMIP promotes it. However, Muc1/EGFR regulated matrix degradation is not Met-dependant. Meanwhile, the transwell invasion assay provided variable and statistically insignificant results.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Physiology
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleMatrix Degradation and Invasion in Breast Canceren_US
dc.creatorStarobinska, Ellaen_US
dc.contributor.authorStarobinska, Ellaen_US
dc.date.issued2012-05-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractIn order to metastasize, cancer cells need to invade and degrade matrix. Previous research showed that Epidermal Growth Factor Receptor (EGFR) is an oncogene, a member of ErBb family, that is over-expressed in aggressive cancers. EGFR mediates cell survival, proliferation, and motility through different signaling pathways. Located on the basolateral membrane of the cell, EGFR can be either translocated to the nucleus, degraded by the lysosome or recycled. However, in cancerous cells, EGFR activity is altered by MUC1, which associates itself with EGFR. Research suggested that this pathway acts in a Met-dependent manner. We conducted matrix degradation and invasion assays to see whether MUC1/EGFR activity has affect on these processes. Matrix degradation assay showed that Muc1 and EGFR inhibit matrix degradation and PMIP promotes it. However, Muc1/EGFR regulated matrix degradation is not Met-dependant. Meanwhile, the transwell invasion assay provided variable and statistically insignificant results.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameB.S.en_US
thesis.degree.levelbachelorsen_US
thesis.degree.disciplineHonors Collegeen_US
thesis.degree.disciplinePhysiologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
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