Molecular Variation in the Agouti Gene in Pocket Mice from the Carrizozo Malpaís Lava Flow

Persistent Link:
http://hdl.handle.net/10150/244481
Title:
Molecular Variation in the Agouti Gene in Pocket Mice from the Carrizozo Malpaís Lava Flow
Author:
Moore, Jillian Nicole
Issue Date:
May-2012
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Color variation in pocket mice, Chaetodipus intermedius, presents a unique opportunity to study genes contributing to convergent adaptation. While pocket mice generally have light coats matching sand-colored rocks on which they live, dark mice are found on basalt lava flows in the desert southwest. Because the mice match their habitat, they are less likely to be recognized by visual hunters. In one lava flow population, the genetic basis of melanism was identified in the melanocortin-1 receptor (Mc1r). However, it is known that the underlying locus is different in a lava flow population in Carrizozo, NM. In a backcross, it was demonstrated that melanism in Carrizozo is recessive and associated with a marker in agouti, a locus encoding an MC1R antagonist. However, because of the low level of recombination in this cross, genes linked to this marker could underlie color variation. Here, I sequenced regions of agouti previously uncharacterized in pocket mice. I genotyped Carrizozo mice in these regions and identified a SNP significantly associated with coat color likely linked to a causative mutation within agouti. These data support the hypothesis that melanism has arisen at least twice in pocket mice due to changes in different pigmentation genes, Mc1r and agouti.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Molecular and Cellular Biology
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleMolecular Variation in the Agouti Gene in Pocket Mice from the Carrizozo Malpaís Lava Flowen_US
dc.creatorMoore, Jillian Nicoleen_US
dc.contributor.authorMoore, Jillian Nicoleen_US
dc.date.issued2012-05-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractColor variation in pocket mice, Chaetodipus intermedius, presents a unique opportunity to study genes contributing to convergent adaptation. While pocket mice generally have light coats matching sand-colored rocks on which they live, dark mice are found on basalt lava flows in the desert southwest. Because the mice match their habitat, they are less likely to be recognized by visual hunters. In one lava flow population, the genetic basis of melanism was identified in the melanocortin-1 receptor (Mc1r). However, it is known that the underlying locus is different in a lava flow population in Carrizozo, NM. In a backcross, it was demonstrated that melanism in Carrizozo is recessive and associated with a marker in agouti, a locus encoding an MC1R antagonist. However, because of the low level of recombination in this cross, genes linked to this marker could underlie color variation. Here, I sequenced regions of agouti previously uncharacterized in pocket mice. I genotyped Carrizozo mice in these regions and identified a SNP significantly associated with coat color likely linked to a causative mutation within agouti. These data support the hypothesis that melanism has arisen at least twice in pocket mice due to changes in different pigmentation genes, Mc1r and agouti.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameB.S.en_US
thesis.degree.levelbachelorsen_US
thesis.degree.disciplineHonors Collegeen_US
thesis.degree.disciplineMolecular and Cellular Biologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
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