Persistent Link:
http://hdl.handle.net/10150/243959
Title:
Bad Blood: Cons of Synthetic Blood Substitutes
Author:
Guerra, Andres
Issue Date:
May-2012
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
In recent years scientists have been attempting to develop synthetic blood substitutes in order to counter both the shortage in donor blood and the problems associated with infection and disease during allogeneic transfusion. Most attempts have been made at mimicking the oxygen carrying capabilities of red blood cells yet there is still a broad array of substances in use today that try to simulate the effects of whole blood, not just the red blood cell itself. This literature based thesis extensively discuses the importance of all blood components and reviews the recent developments and problems associated with volume expanders, oxygen carriers which are further subcategorized into hemoglobin-based substitutes and perfluorocarbons, erythropoietin use, and autologous blood transfusions. Their short term use has potential benefits but in the long term some of their shortcomings include hypertension, hypoproteinemia, thrombus formation, abnormal vasoactivity, anaphylaxis, and ischemic reperfusion injury, all of which tend to overshadow their benefits.
Type:
text; Electronic Thesis
Degree Name:
B.S.H.S.
Degree Level:
bachelors
Degree Program:
Honors College; Physiology
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleBad Blood: Cons of Synthetic Blood Substitutesen_US
dc.creatorGuerra, Andresen_US
dc.contributor.authorGuerra, Andresen_US
dc.date.issued2012-05-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractIn recent years scientists have been attempting to develop synthetic blood substitutes in order to counter both the shortage in donor blood and the problems associated with infection and disease during allogeneic transfusion. Most attempts have been made at mimicking the oxygen carrying capabilities of red blood cells yet there is still a broad array of substances in use today that try to simulate the effects of whole blood, not just the red blood cell itself. This literature based thesis extensively discuses the importance of all blood components and reviews the recent developments and problems associated with volume expanders, oxygen carriers which are further subcategorized into hemoglobin-based substitutes and perfluorocarbons, erythropoietin use, and autologous blood transfusions. Their short term use has potential benefits but in the long term some of their shortcomings include hypertension, hypoproteinemia, thrombus formation, abnormal vasoactivity, anaphylaxis, and ischemic reperfusion injury, all of which tend to overshadow their benefits.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameB.S.H.S.en_US
thesis.degree.levelbachelorsen_US
thesis.degree.disciplineHonors Collegeen_US
thesis.degree.disciplinePhysiologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
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