Persistent Link:
http://hdl.handle.net/10150/243955
Title:
NO/HNO Releasing Derivatives of Chlorambucil and Aspirin
Author:
Giridharan, Kavya Sindhu
Issue Date:
May-2012
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Nitric oxide (NO) is a critical compound for many physiological processes and is closely connected to diseases such as cancer and pathophysiological conditions such as stroke and heart failure. NO synthesis is crucial for vasodilation and reduces blood clot formation. It is known to reduce glutathione (GSH), an inhibitor of cancer-therapy drugs, through oxidation of its thiol group. Combining chlorambucil, a chemotherapy drug that is used to treat chronic lymphocytic leukemia, and an NO releasing compound is projected to increase drug-therapy effectiveness on resistant cell line. Non-steroidal antiinflammatory drugs (NSAIDS) can also be combined with NO donors to create a drug that is both anti-inflammatory and anti-cancer.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Biochemistry and Molecular Biophysics
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleNO/HNO Releasing Derivatives of Chlorambucil and Aspirinen_US
dc.creatorGiridharan, Kavya Sindhuen_US
dc.contributor.authorGiridharan, Kavya Sindhuen_US
dc.date.issued2012-05-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractNitric oxide (NO) is a critical compound for many physiological processes and is closely connected to diseases such as cancer and pathophysiological conditions such as stroke and heart failure. NO synthesis is crucial for vasodilation and reduces blood clot formation. It is known to reduce glutathione (GSH), an inhibitor of cancer-therapy drugs, through oxidation of its thiol group. Combining chlorambucil, a chemotherapy drug that is used to treat chronic lymphocytic leukemia, and an NO releasing compound is projected to increase drug-therapy effectiveness on resistant cell line. Non-steroidal antiinflammatory drugs (NSAIDS) can also be combined with NO donors to create a drug that is both anti-inflammatory and anti-cancer.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameB.S.en_US
thesis.degree.levelbachelorsen_US
thesis.degree.disciplineHonors Collegeen_US
thesis.degree.disciplineBiochemistry and Molecular Biophysicsen_US
thesis.degree.grantorUniversity of Arizonaen_US
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