The Effects of Nicotine Exposure on the Respiratory Rhythm Generator of Neonatal Rats

Persistent Link:
http://hdl.handle.net/10150/243875
Title:
The Effects of Nicotine Exposure on the Respiratory Rhythm Generator of Neonatal Rats
Author:
Burns, Whitney Elizabeth
Issue Date:
May-2012
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Many children are exposed to environmental tobacco smoke prenatally and postnatally, which can have adverse health affects throughout life, induding an increased risk of low birth weight, Sudden Infant Death Syndrome (SIDS), obstructive lung disease, cancers, childhood infections, and altered neurodevelopment. The goal of this study was to determine whether postnatal nicotine exposure affects the respiratory rhythm generator in neonatal rats. Brainstem spinal cord preparations from neonatal rats will be exposed to small amounts of nicotine. Spontaneous respiratory activity from C4-C5 ventral roots were recorded with glass suction electrodes. C4-C5 ventral roots contain the phrenic motor axons that supply the diaphragm musde. The results indicate that nicotine exposure affects the respiratory rhythm generator and causes an increase in respiratory frequency.
Type:
text; Electronic Thesis
Degree Name:
B.S.H.S.
Degree Level:
bachelors
Degree Program:
Honors College; Physiology
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleThe Effects of Nicotine Exposure on the Respiratory Rhythm Generator of Neonatal Ratsen_US
dc.creatorBurns, Whitney Elizabethen_US
dc.contributor.authorBurns, Whitney Elizabethen_US
dc.date.issued2012-05-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractMany children are exposed to environmental tobacco smoke prenatally and postnatally, which can have adverse health affects throughout life, induding an increased risk of low birth weight, Sudden Infant Death Syndrome (SIDS), obstructive lung disease, cancers, childhood infections, and altered neurodevelopment. The goal of this study was to determine whether postnatal nicotine exposure affects the respiratory rhythm generator in neonatal rats. Brainstem spinal cord preparations from neonatal rats will be exposed to small amounts of nicotine. Spontaneous respiratory activity from C4-C5 ventral roots were recorded with glass suction electrodes. C4-C5 ventral roots contain the phrenic motor axons that supply the diaphragm musde. The results indicate that nicotine exposure affects the respiratory rhythm generator and causes an increase in respiratory frequency.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameB.S.H.S.en_US
thesis.degree.levelbachelorsen_US
thesis.degree.disciplineHonors Collegeen_US
thesis.degree.disciplinePhysiologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
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