Persistent Link:
http://hdl.handle.net/10150/229772
Title:
Activision of Reward Pathway by Pain Relief
Author:
Ci, Shuang
Issue Date:
Aug-2011
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Recent progress in the pain research field has shed light on the role of dopaminergic neurotransmission in pain perception. However, the relationship between pain relief and reward, and how pain relief modulates the reward circuitry is not well understood. Previous conditioned place preference studies (CPP) in our laboratory have demonstrated that pain relief is rewarding and established the essential role of the ventral tegmentum area (VTA) in the reward that results from pain relief. Based on these observations, we hypothesized that pain relief will activate neurons in the reward pathway. Using immunohistochemical studies, we investigated changes in cFos-staining, a marker for neural activation, in tyrosine hydroxylase-labeled dopaminergic neurons in the VTA. We found that peripheral nerve block selectively increased staining for cFos in the VTA in rats with hind paw incision pain, indicating activation of reward circuitry upon pain relief. Additionally, many of these c-Fos positive cells in the VTA were also tyrosine hydroxylase (TH) positive, suggesting that these were dopaminergic neurons that may underlie the reward associated with pain relief.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Biochemistry; Molecular & Cellular Biology
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleActivision of Reward Pathway by Pain Reliefen_US
dc.creatorCi, Shuangen_US
dc.contributor.authorCi, Shuangen_US
dc.date.issued2011-08-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractRecent progress in the pain research field has shed light on the role of dopaminergic neurotransmission in pain perception. However, the relationship between pain relief and reward, and how pain relief modulates the reward circuitry is not well understood. Previous conditioned place preference studies (CPP) in our laboratory have demonstrated that pain relief is rewarding and established the essential role of the ventral tegmentum area (VTA) in the reward that results from pain relief. Based on these observations, we hypothesized that pain relief will activate neurons in the reward pathway. Using immunohistochemical studies, we investigated changes in cFos-staining, a marker for neural activation, in tyrosine hydroxylase-labeled dopaminergic neurons in the VTA. We found that peripheral nerve block selectively increased staining for cFos in the VTA in rats with hind paw incision pain, indicating activation of reward circuitry upon pain relief. Additionally, many of these c-Fos positive cells in the VTA were also tyrosine hydroxylase (TH) positive, suggesting that these were dopaminergic neurons that may underlie the reward associated with pain relief.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameB.S.en_US
thesis.degree.levelbachelorsen_US
thesis.degree.disciplineHonors Collegeen_US
thesis.degree.disciplineBiochemistryen_US
thesis.degree.disciplineMolecular & Cellular Biologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
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