Persistent Link:
http://hdl.handle.net/10150/228472
Title:
Effects of pH on the Autoxidation of Nitroxyl
Author:
Buttitta, Lisa Ann
Issue Date:
2012
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The reactive nitric oxide species (RNOS) nitroxyl (HNO) has exhibited both beneficial and deleterious biological effects. In particular, HNO autoxidation can lead to harmful modifications of biomolecules, yet the products of HNO/O₂ remain undetermined. A conceivable product is peroxynitrous acid (ONOOH), however a comparison of the chemistry of HNO/O₂ to synthetic peroxynitrite (ONOO⁻) determined that these RNOS have distinct reactive profiles. This study compares the reactivity of HNO and NO⁻ in the presence of O₂ to synthetic ONOO⁻ and the autoxidation of HNO at high pH (NO⁻/O₂) in an effort to shed light on the products of HNO autoxidation. All species exhibited the capacity for two-electron oxidation, but differences between ONOO⁻ and NO⁻/O₂ and HNO/O₂ were observed in terms of one-electron oxidation, hydroxylation, nitration and buffer effects. NO⁻/O₂ exhibited a reactive profile similar to ONOO⁻, suggesting that protonation of ONOO⁻leads to a unique species from the autoxidation of HNO.
Type:
text; Electronic Thesis
Keywords:
Nitroxyl; pH Effects; Chemistry; Autoxidation; HNO
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Chemistry
Degree Grantor:
University of Arizona
Advisor:
Miranda, Katrina M.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleEffects of pH on the Autoxidation of Nitroxylen_US
dc.creatorButtitta, Lisa Annen_US
dc.contributor.authorButtitta, Lisa Annen_US
dc.date.issued2012-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe reactive nitric oxide species (RNOS) nitroxyl (HNO) has exhibited both beneficial and deleterious biological effects. In particular, HNO autoxidation can lead to harmful modifications of biomolecules, yet the products of HNO/O₂ remain undetermined. A conceivable product is peroxynitrous acid (ONOOH), however a comparison of the chemistry of HNO/O₂ to synthetic peroxynitrite (ONOO⁻) determined that these RNOS have distinct reactive profiles. This study compares the reactivity of HNO and NO⁻ in the presence of O₂ to synthetic ONOO⁻ and the autoxidation of HNO at high pH (NO⁻/O₂) in an effort to shed light on the products of HNO autoxidation. All species exhibited the capacity for two-electron oxidation, but differences between ONOO⁻ and NO⁻/O₂ and HNO/O₂ were observed in terms of one-electron oxidation, hydroxylation, nitration and buffer effects. NO⁻/O₂ exhibited a reactive profile similar to ONOO⁻, suggesting that protonation of ONOO⁻leads to a unique species from the autoxidation of HNO.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
dc.subjectNitroxylen_US
dc.subjectpH Effectsen_US
dc.subjectChemistryen_US
dc.subjectAutoxidationen_US
dc.subjectHNOen_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorMiranda, Katrina M.en_US
dc.contributor.committeememberLichtenberger, Dennis L.en_US
dc.contributor.committeememberMontfort, William R.en_US
dc.contributor.committeememberMiranda, Katrina M.en_US
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