Role of Surface Molecules in Campylobacter jejuni Colonization and Virulence in Chickens

Persistent Link:
http://hdl.handle.net/10150/228452
Title:
Role of Surface Molecules in Campylobacter jejuni Colonization and Virulence in Chickens
Author:
Echevarría-Núñez, Lisbeth E.
Issue Date:
2012
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Campylobacter spp. is one of the two major causes of foodborne illness throughout the world. Campylobacter accounts for the most common causes of diarrheal illness caused by bacterial pathogens worldwide and in the United States. It is estimated that Campylobacter diarrheal illness affects about 2.4 million persons every year with an estimated cost of treatment and loss of productivity exceeding $1 billion annually. Previous work in our laboratory on biofilms has demonstrated the presence pilus-like surface-associated structures disseminating from the cell wall of C. jejuni isolates not expressing flagella (flaAB mutants). To further investigate this finding, bioinformatics analysis, purification and identification of genes involved in the expression of surface-associated structures as well as mutational analysis of putative genes were performed. We identified two important poultry colonization factors in C. jejuni. These studies might provide insights in understanding the pathogenesis of C. jejuni. Moreover, it will provide a new target for potential vaccine development against C. jejuni infection in poultry production system. Thus directly impacting the number of C. jejuni infection in humans.
Type:
text; Electronic Dissertation
Keywords:
Microbiology
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Microbiology
Degree Grantor:
University of Arizona
Advisor:
Joens, Lynn A.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleRole of Surface Molecules in Campylobacter jejuni Colonization and Virulence in Chickensen_US
dc.creatorEchevarría-Núñez, Lisbeth E.en_US
dc.contributor.authorEchevarría-Núñez, Lisbeth E.en_US
dc.date.issued2012-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractCampylobacter spp. is one of the two major causes of foodborne illness throughout the world. Campylobacter accounts for the most common causes of diarrheal illness caused by bacterial pathogens worldwide and in the United States. It is estimated that Campylobacter diarrheal illness affects about 2.4 million persons every year with an estimated cost of treatment and loss of productivity exceeding $1 billion annually. Previous work in our laboratory on biofilms has demonstrated the presence pilus-like surface-associated structures disseminating from the cell wall of C. jejuni isolates not expressing flagella (flaAB mutants). To further investigate this finding, bioinformatics analysis, purification and identification of genes involved in the expression of surface-associated structures as well as mutational analysis of putative genes were performed. We identified two important poultry colonization factors in C. jejuni. These studies might provide insights in understanding the pathogenesis of C. jejuni. Moreover, it will provide a new target for potential vaccine development against C. jejuni infection in poultry production system. Thus directly impacting the number of C. jejuni infection in humans.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.subjectMicrobiologyen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineMicrobiologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorJoens, Lynn A.en_US
dc.contributor.committeememberViswanathan, V. K.en_US
dc.contributor.committeememberReggiardo, Carlosen_US
dc.contributor.committeememberRavishankar, Sadhanaen_US
dc.contributor.committeememberJoens, Lynn A.en_US
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