Evaluating Chemopreventive and Chemotherapeutic Agent Effectiveness in a Mouse Model of Sporadic Colorectal Cancer Using Optical Coherence Tomography

Persistent Link:
http://hdl.handle.net/10150/228440
Title:
Evaluating Chemopreventive and Chemotherapeutic Agent Effectiveness in a Mouse Model of Sporadic Colorectal Cancer Using Optical Coherence Tomography
Author:
LeGendre-McGhee, Susan
Issue Date:
2012
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Optical coherence tomography (OCT) is a minimally-invasive imaging modality that generates high resolution cross-sectional images of tissue. The present study employed a 2 mm diameter endoscopic spectral domain OCT system in the in vivo evaluation of the drugs α-Difluoromethylornithine and Sulindac as chemopreventive and chemotherapeutic agents in a mouse model of sporadic colorectal cancer. 30 mm lateral images of each colon at eight different rotations were obtained at five different time points. Visual analysis of the images was performed to determine the number and size of discrete adenomas, with gross photos and histology serving as gold standard confirmation of the final imaging time point. When applied for chemoprevention, DFMO and Sulindac both significantly reduced the incidence of adenoma, appearing to interact additively in the prevention of tumorigenesis. For chemotherapy, however, only Sulindac had a significant effect on the number of adenoma and neither DFMO nor Sulindac significantly affected tumor growth.
Type:
text; Electronic Thesis
Keywords:
colorectal cancer; interferometry; mouse model; optical coherence tomography; Biomedical Engineering; chemoprevention; chemotherapy
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Biomedical Engineering
Degree Grantor:
University of Arizona
Advisor:
Barton, Jennifer K.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleEvaluating Chemopreventive and Chemotherapeutic Agent Effectiveness in a Mouse Model of Sporadic Colorectal Cancer Using Optical Coherence Tomographyen_US
dc.creatorLeGendre-McGhee, Susanen_US
dc.contributor.authorLeGendre-McGhee, Susanen_US
dc.date.issued2012-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractOptical coherence tomography (OCT) is a minimally-invasive imaging modality that generates high resolution cross-sectional images of tissue. The present study employed a 2 mm diameter endoscopic spectral domain OCT system in the in vivo evaluation of the drugs α-Difluoromethylornithine and Sulindac as chemopreventive and chemotherapeutic agents in a mouse model of sporadic colorectal cancer. 30 mm lateral images of each colon at eight different rotations were obtained at five different time points. Visual analysis of the images was performed to determine the number and size of discrete adenomas, with gross photos and histology serving as gold standard confirmation of the final imaging time point. When applied for chemoprevention, DFMO and Sulindac both significantly reduced the incidence of adenoma, appearing to interact additively in the prevention of tumorigenesis. For chemotherapy, however, only Sulindac had a significant effect on the number of adenoma and neither DFMO nor Sulindac significantly affected tumor growth.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
dc.subjectcolorectal canceren_US
dc.subjectinterferometryen_US
dc.subjectmouse modelen_US
dc.subjectoptical coherence tomographyen_US
dc.subjectBiomedical Engineeringen_US
dc.subjectchemopreventionen_US
dc.subjectchemotherapyen_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineBiomedical Engineeringen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorBarton, Jennifer K.en_US
dc.contributor.committeememberUtzinger, Ursen_US
dc.contributor.committeememberBilgin, Alien_US
dc.contributor.committeememberIgnatenko, Nataliaen_US
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