A Sweet Cherry Feeding Trial in Healthy, Overweight Males: Anthocyanin Bioavailability and Inflammatory Biomarker Response

Persistent Link:
http://hdl.handle.net/10150/203500
Title:
A Sweet Cherry Feeding Trial in Healthy, Overweight Males: Anthocyanin Bioavailability and Inflammatory Biomarker Response
Author:
Diemert, Lindsey
Issue Date:
2011
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Background: Low-grade chronic inflammation has been implicated as a risk factor in prostate-related pathologies including benign hyperplasia and cancer. Sweet cherry containing the bioactive anthocyanin (ACN), has demonstrated tumor inhibitory action in model systems, specifically inhibition of inflammatory molecules and prostaglandin biosynthesis. Objective: To assess the urinary and plasma concentrations of ACN from the daily consumption of 3 cups of sweet cherries for 4 weeks and test the relationship of ACN levels and cherry consumption to inflammatory biomarkers in an at risk population. Results: Prostaglandin E2 Metabolite (PGEM) levels were reduced with cherry consumption in men with elevated baseline values. Conclusion: We conclude that 1c (142g) of sweet cherries 3 times daily for 4 weeks significantly reduced the COX-2 metabolite, PGEM, in men with elevated baseline levels. This was the first study to examine the chronic effects of daily sweet cherries on COX-2 inhibition in an at risk population.
Type:
text; Electronic Thesis
Keywords:
Inflammation; Prostaglandin E2; Prostate Cancer; Sweet Cherry; Nutritional Sciences; Anthocyanin; Cyanidin
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Nutritional Sciences
Degree Grantor:
University of Arizona
Advisor:
Thompson, Patricia

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleA Sweet Cherry Feeding Trial in Healthy, Overweight Males: Anthocyanin Bioavailability and Inflammatory Biomarker Responseen_US
dc.creatorDiemert, Lindseyen_US
dc.contributor.authorDiemert, Lindseyen_US
dc.date.issued2011-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractBackground: Low-grade chronic inflammation has been implicated as a risk factor in prostate-related pathologies including benign hyperplasia and cancer. Sweet cherry containing the bioactive anthocyanin (ACN), has demonstrated tumor inhibitory action in model systems, specifically inhibition of inflammatory molecules and prostaglandin biosynthesis. Objective: To assess the urinary and plasma concentrations of ACN from the daily consumption of 3 cups of sweet cherries for 4 weeks and test the relationship of ACN levels and cherry consumption to inflammatory biomarkers in an at risk population. Results: Prostaglandin E2 Metabolite (PGEM) levels were reduced with cherry consumption in men with elevated baseline values. Conclusion: We conclude that 1c (142g) of sweet cherries 3 times daily for 4 weeks significantly reduced the COX-2 metabolite, PGEM, in men with elevated baseline levels. This was the first study to examine the chronic effects of daily sweet cherries on COX-2 inhibition in an at risk population.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
dc.subjectInflammationen_US
dc.subjectProstaglandin E2en_US
dc.subjectProstate Canceren_US
dc.subjectSweet Cherryen_US
dc.subjectNutritional Sciencesen_US
dc.subjectAnthocyaninen_US
dc.subjectCyanidinen_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineNutritional Sciencesen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorThompson, Patriciaen_US
dc.contributor.committeememberBurd, Randyen_US
dc.contributor.committeememberThompson, Patriciaen_US
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