The Effects of Deep Brain Stimulation on Deglutition in Parkinson Disease

Persistent Link:
http://hdl.handle.net/10150/195514
Title:
The Effects of Deep Brain Stimulation on Deglutition in Parkinson Disease
Author:
Ciucci, Michelle Renee
Issue Date:
2006
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Relatively little is known about the role of the basal ganglia and their pathways in human deglutition. Deep Brain Stimulation (DBS) is a treatment for Parkinson Disease (PD) that stimulates the subthalamic nuclei and affords us a model for examining deglutition in humans with known impairment of the basal ganglia. The purpose of this study was to examine the effects of DBS in the ON versus Off conditions on the oral and pharyngeal stages of deglutition in participants with PD. It was hypothesized that DBS in the ON condition would yield improvement in the following dependent variables: oral total composite score, pharyngeal total composite score, pharyngeal transit time, and maximal hyoid bone excursion. Statistically significant differences (improvement) were found for the pharyngeal composite score and pharyngeal transit time in the DBS ON condition. Findings of this study demonstrated that DBS in the ON condition helps to alleviate some of the bradykinesia and hypokinesia associated with PD on the pharyngeal stage of deglutition, but not the oral stage. These findings suggest that Parkinsonian swallowing dysfunction is not solely related to nigrostriatal dopamine deficiency which is purported to be the primary means of DBS alleviation of motor signs. Rather, it may be due to an additional non-dopamine related system of deglutition found in the brainstem.
Type:
text; Electronic Dissertation
Keywords:
deep brain stimulation; deglutition; parkinson disease; swallowing; motor control
Degree Name:
PhD
Degree Level:
doctoral
Degree Program:
Speech, Language, & Hearing Sciences; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Barkmeier-Kraemer, Julie M.
Committee Chair:
Barkmeier-Kraemer, Julie M.

Full metadata record

DC FieldValue Language
dc.language.isoENen_US
dc.titleThe Effects of Deep Brain Stimulation on Deglutition in Parkinson Diseaseen_US
dc.creatorCiucci, Michelle Reneeen_US
dc.contributor.authorCiucci, Michelle Reneeen_US
dc.date.issued2006en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractRelatively little is known about the role of the basal ganglia and their pathways in human deglutition. Deep Brain Stimulation (DBS) is a treatment for Parkinson Disease (PD) that stimulates the subthalamic nuclei and affords us a model for examining deglutition in humans with known impairment of the basal ganglia. The purpose of this study was to examine the effects of DBS in the ON versus Off conditions on the oral and pharyngeal stages of deglutition in participants with PD. It was hypothesized that DBS in the ON condition would yield improvement in the following dependent variables: oral total composite score, pharyngeal total composite score, pharyngeal transit time, and maximal hyoid bone excursion. Statistically significant differences (improvement) were found for the pharyngeal composite score and pharyngeal transit time in the DBS ON condition. Findings of this study demonstrated that DBS in the ON condition helps to alleviate some of the bradykinesia and hypokinesia associated with PD on the pharyngeal stage of deglutition, but not the oral stage. These findings suggest that Parkinsonian swallowing dysfunction is not solely related to nigrostriatal dopamine deficiency which is purported to be the primary means of DBS alleviation of motor signs. Rather, it may be due to an additional non-dopamine related system of deglutition found in the brainstem.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.subjectdeep brain stimulationen_US
dc.subjectdeglutitionen_US
dc.subjectparkinson diseaseen_US
dc.subjectswallowingen_US
dc.subjectmotor controlen_US
thesis.degree.namePhDen_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineSpeech, Language, & Hearing Sciencesen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorBarkmeier-Kraemer, Julie M.en_US
dc.contributor.chairBarkmeier-Kraemer, Julie M.en_US
dc.contributor.committeememberBarkmeier-Kraemer, Julie M.en_US
dc.contributor.committeememberHoit, Jennyen_US
dc.contributor.committeememberPlante, Elenaen_US
dc.contributor.committeememberSherman, Scotten_US
dc.contributor.committeememberFuglevand, Andyen_US
dc.identifier.proquest1505en_US
dc.identifier.oclc137356700en_US
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