High Numerical Aperture Injection-Molded Miniature Objective For Fiber-Optic Confocal Reflectance Microscopy

Persistent Link:
http://hdl.handle.net/10150/195480
Title:
High Numerical Aperture Injection-Molded Miniature Objective For Fiber-Optic Confocal Reflectance Microscopy
Author:
Chidley, Matthew D.
Issue Date:
2005
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
This dissertation presents the design of a miniature injection-molded objective lens for a fiber-optic confocal reflectance microscope. This is part of an effort to demonstrate the ability to fabricate low cost, high performance biomedical optics for high resolution in vivo imaging. Disposable endoscopic microscope objectives could help in vivo confocal microscopy technology mature to enable large-scale clinical screening and detection of early cancers and pre-cancerous lesions. This five lens plastic objective has been tested as a stand-alone optical system and has been coupled to a confocal microscope for in vivo imaging of cells and tissue. Changing the spacing and rotation of the individual optical elements can compensate for fabrication inaccuracies and improve performance. An optical-bench testing system was constructed to allow interactive alignment during testing. The modulation transfer function (MTF) of the miniature objective lens is determined using the slanted-edge method. A custom MATLAB program, edgeMTF, was written to collect, analyize, and record test data. An estimated Strehl ratio of 0.64 and an MTF value of 0.70, at the fiber-optic bundle Nyquist frequency, have been obtained. The main performance limitations of the miniature objective are mechanical alignment and flow-induced birefringence. Annealing and experimental injection molding runs were conducted in effort to reduce birefringence.
Type:
text; Electronic Dissertation
Keywords:
Optical design; endoscope objectives; Fiber Confocal Reflectance Microscopy; Optical testing
Degree Name:
PhD
Degree Level:
doctoral
Degree Program:
Optical Sciences; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Descour, Michael R.
Committee Chair:
Descour, Michael R.

Full metadata record

DC FieldValue Language
dc.language.isoENen_US
dc.titleHigh Numerical Aperture Injection-Molded Miniature Objective For Fiber-Optic Confocal Reflectance Microscopyen_US
dc.creatorChidley, Matthew D.en_US
dc.contributor.authorChidley, Matthew D.en_US
dc.date.issued2005en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThis dissertation presents the design of a miniature injection-molded objective lens for a fiber-optic confocal reflectance microscope. This is part of an effort to demonstrate the ability to fabricate low cost, high performance biomedical optics for high resolution in vivo imaging. Disposable endoscopic microscope objectives could help in vivo confocal microscopy technology mature to enable large-scale clinical screening and detection of early cancers and pre-cancerous lesions. This five lens plastic objective has been tested as a stand-alone optical system and has been coupled to a confocal microscope for in vivo imaging of cells and tissue. Changing the spacing and rotation of the individual optical elements can compensate for fabrication inaccuracies and improve performance. An optical-bench testing system was constructed to allow interactive alignment during testing. The modulation transfer function (MTF) of the miniature objective lens is determined using the slanted-edge method. A custom MATLAB program, edgeMTF, was written to collect, analyize, and record test data. An estimated Strehl ratio of 0.64 and an MTF value of 0.70, at the fiber-optic bundle Nyquist frequency, have been obtained. The main performance limitations of the miniature objective are mechanical alignment and flow-induced birefringence. Annealing and experimental injection molding runs were conducted in effort to reduce birefringence.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.subjectOptical designen_US
dc.subjectendoscope objectivesen_US
dc.subjectFiber Confocal Reflectance Microscopyen_US
dc.subjectOptical testingen_US
thesis.degree.namePhDen_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineOptical Sciencesen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorDescour, Michael R.en_US
dc.contributor.chairDescour, Michael R.en_US
dc.contributor.committeememberGmitro, Arthur F.en_US
dc.contributor.committeememberRichards-Kortum, Rebecca R.en_US
dc.contributor.committeememberTkaczyk, Tomaszen_US
dc.identifier.proquest1300en_US
dc.identifier.oclc137354899en_US
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