Persistent Link:
http://hdl.handle.net/10150/195293
Title:
MRI OF TUMOR pH AND PERFUSION
Author:
Zhang, Xiaomeng
Issue Date:
2010
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
In the early 1920s, Otto Warburg demonstrated that tumor cells have a capacity to convert glucose and other substrates into lactic acid instead of CO2 and water, even under aerobic conditions. Consequently, Warburg assumed that the intracellular pH (pHi) of tumor was acidic. However, later studies have shown that maintenance of pHi within a pH range of 7.0-7.2 is necessary for normal cellular proliferation and that the extracellular pH (pHe) is partially acidic in solid tumors. A low pHe may be an important factor inducing invasive behavior in tumor cells. Research into causes and consequences of this acid pH of tumors are highly dependent on accurate, precise and reproducible measurements. Techniques for measuring tissue pHi and pHe have undergone great changes since 1950s. From microelectrode and dye distribution studies, measurement of pH underwent a revolution with the advent of pH-sensitive dyes that could be loaded into the cytosol. Further significant advances have come from the measurement of cell and tissue pH in whole organisms by magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI) and pH-sensitive Positron Emission Tomography (PET) radiotracers.
Type:
text; Electronic Dissertation
Keywords:
Perfusion MRI; pH imaging; Tumor microenvironment; Tumor pH; Tumor vasculature
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Biomedical Engineering; Graduate College
Degree Grantor:
University of Arizona
Committee Chair:
Pagel, Mark D.

Full metadata record

DC FieldValue Language
dc.language.isoENen_US
dc.titleMRI OF TUMOR pH AND PERFUSIONen_US
dc.creatorZhang, Xiaomengen_US
dc.contributor.authorZhang, Xiaomengen_US
dc.date.issued2010en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractIn the early 1920s, Otto Warburg demonstrated that tumor cells have a capacity to convert glucose and other substrates into lactic acid instead of CO2 and water, even under aerobic conditions. Consequently, Warburg assumed that the intracellular pH (pHi) of tumor was acidic. However, later studies have shown that maintenance of pHi within a pH range of 7.0-7.2 is necessary for normal cellular proliferation and that the extracellular pH (pHe) is partially acidic in solid tumors. A low pHe may be an important factor inducing invasive behavior in tumor cells. Research into causes and consequences of this acid pH of tumors are highly dependent on accurate, precise and reproducible measurements. Techniques for measuring tissue pHi and pHe have undergone great changes since 1950s. From microelectrode and dye distribution studies, measurement of pH underwent a revolution with the advent of pH-sensitive dyes that could be loaded into the cytosol. Further significant advances have come from the measurement of cell and tissue pH in whole organisms by magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI) and pH-sensitive Positron Emission Tomography (PET) radiotracers.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.subjectPerfusion MRIen_US
dc.subjectpH imagingen_US
dc.subjectTumor microenvironmenten_US
dc.subjectTumor pHen_US
dc.subjectTumor vasculatureen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineBiomedical Engineeringen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.chairPagel, Mark D.en_US
dc.contributor.committeememberGillies, Robert J.en_US
dc.contributor.committeememberTrouard, Theodore P.en_US
dc.contributor.committeememberGmitro, Arthur F.en_US
dc.contributor.committeememberUtzinger, Ursen_US
dc.identifier.proquest10966en_US
dc.identifier.oclc659754890en_US
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