Persistent Link:
http://hdl.handle.net/10150/195225
Title:
Analog Signal Processing for Optical Coherence Imaging Systems
Author:
Xu, Wei
Issue Date:
2006
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Optical coherence tomography (OCT) and optical coherence microscopy (OCM) are non-invasive optical coherence imaging techniques, which enable micron-scale resolution, depth resolved imaging capability. Both OCT and OCM are based on Michelson interferometer theory. They are widely used in ophthalmology, gastroenterology and dermatology, because of their high resolution, safety and low cost. OCT creates cross sectional images whereas OCM obtains en face images. In this dissertation, the design and development of three increasingly complicated analog signal processing (ASP) solutions for optical coherence imaging are presented.The first ASP solution was implemented for a time domain OCT system with a Rapid Scanning Optical Delay line (RSOD)-based optical signal modulation and logarithmic amplifier (Log amp) based demodulation. This OCT system can acquire up to 1600 A-scans per second. The measured dynamic range is 106dB at 200A-scan per second. This OCT signal processing electronics includes an off-the-shelf filter box with a Log amp circuit implemented on a PCB board.The second ASP solution was developed for an OCM system with synchronized modulation and demodulation and compensation for interferometer phase drift. This OCM acquired micron-scale resolution, high dynamic range images at acquisition speeds up to 45,000 pixels/second. This OCM ASP solution is fully custom designed on a perforated circuit board.The third ASP solution was implemented on a single 2.2 mm x 2.2 mm complementary metal oxide semiconductor (CMOS) chip. This design is expandable to a multiple channel OCT system. A single on-chip CMOS photodetector and ASP channel was used for coherent demodulation in a time domain OCT system. Cross-sectional images were acquired with a dynamic range of 76dB (limited by photodetector responsivity). When incorporated with a bump-bonded InGaAs photodiode with higher responsivity, the expected dynamic range is close to 100dB.
Type:
text; Electronic Dissertation
Keywords:
optical coherence tomography; optical coherence microscopy; CMOS; analog circuit; transimpedance; demodulation
Degree Name:
DEng
Degree Level:
doctoral
Degree Program:
Systems & Industrial Engineering; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Wang, Feiyue; Barton, Jennifer K.
Committee Chair:
Wang, Feiyue; Barton, Jennifer K.

Full metadata record

DC FieldValue Language
dc.language.isoENen_US
dc.titleAnalog Signal Processing for Optical Coherence Imaging Systemsen_US
dc.creatorXu, Weien_US
dc.contributor.authorXu, Weien_US
dc.date.issued2006en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractOptical coherence tomography (OCT) and optical coherence microscopy (OCM) are non-invasive optical coherence imaging techniques, which enable micron-scale resolution, depth resolved imaging capability. Both OCT and OCM are based on Michelson interferometer theory. They are widely used in ophthalmology, gastroenterology and dermatology, because of their high resolution, safety and low cost. OCT creates cross sectional images whereas OCM obtains en face images. In this dissertation, the design and development of three increasingly complicated analog signal processing (ASP) solutions for optical coherence imaging are presented.The first ASP solution was implemented for a time domain OCT system with a Rapid Scanning Optical Delay line (RSOD)-based optical signal modulation and logarithmic amplifier (Log amp) based demodulation. This OCT system can acquire up to 1600 A-scans per second. The measured dynamic range is 106dB at 200A-scan per second. This OCT signal processing electronics includes an off-the-shelf filter box with a Log amp circuit implemented on a PCB board.The second ASP solution was developed for an OCM system with synchronized modulation and demodulation and compensation for interferometer phase drift. This OCM acquired micron-scale resolution, high dynamic range images at acquisition speeds up to 45,000 pixels/second. This OCM ASP solution is fully custom designed on a perforated circuit board.The third ASP solution was implemented on a single 2.2 mm x 2.2 mm complementary metal oxide semiconductor (CMOS) chip. This design is expandable to a multiple channel OCT system. A single on-chip CMOS photodetector and ASP channel was used for coherent demodulation in a time domain OCT system. Cross-sectional images were acquired with a dynamic range of 76dB (limited by photodetector responsivity). When incorporated with a bump-bonded InGaAs photodiode with higher responsivity, the expected dynamic range is close to 100dB.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.subjectoptical coherence tomographyen_US
dc.subjectoptical coherence microscopyen_US
dc.subjectCMOSen_US
dc.subjectanalog circuiten_US
dc.subjecttransimpedanceen_US
dc.subjectdemodulationen_US
thesis.degree.nameDEngen_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineSystems & Industrial Engineeringen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorWang, Feiyueen_US
dc.contributor.advisorBarton, Jennifer K.en_US
dc.contributor.chairWang, Feiyueen_US
dc.contributor.chairBarton, Jennifer K.en_US
dc.contributor.committeememberSzidarovszky, Ferencen_US
dc.contributor.committeememberMathine, David L.en_US
dc.identifier.proquest1694en_US
dc.identifier.oclc659746284en_US
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