RESISTANCE TRAINING AND MEASURES OF INFLAMMATION IN RELATION TO BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN

Persistent Link:
http://hdl.handle.net/10150/194839
Title:
RESISTANCE TRAINING AND MEASURES OF INFLAMMATION IN RELATION TO BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN
Author:
Stanescu, Claudia Ioana
Issue Date:
2005
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The purpose of this study was to determine the role of body composition and fat distribution on C-reactive protein (CRP) and interleukin-6 (IL-6); determine the differences in CRP and IL-6 among HT users and non-users; determine the effect of 12-months of resistance training and resulting body composition changes on IL-6 and CRP; determine the relationship between BMD and IL-6, CRP and creatine kinase (CK). Sedentary women (N=208, age 44-66, 3-10 years postmenopausal) taking HT (N=106) or not taking HT (N=102) were randomly assigned to resistance training: HTexercise (N=55), HT-no exercise (N=45), no HT-exercise (N=53), and no HT-no exercise (N=49). The program included three weekly 60-75 minute sessions of 8 exercises performed in 2 sets of 6-8 repetitions at 70-80% of 1RM. Total fat mass (TFM), lean soft tissue mass (LSTM) and BMD were assessed by dual-energy X-ray absorptiometry (DXA). Abdominal fat mass (AFM) was assessed using DXA region of interest. For each subject, baseline and 1- year IL-6, CRP and CK were measured. High TFM, high IL-6 and HT use were independently associated with high CRP levels. A stronger relationship between IL-6 and AFM compared to TFM was found in HT users. High TFM and LSTM were significantly related to higher IL-6 levels. A stronger relationship between CRP and AFM compared to TFM was found in HT non-users. CRP was higher in HT users (5.47±5.40 mg/L) compared to non-users (2.70±3.05 mg/L) and was higher in oral (5.76±5.29 mg/L opposed; 6.14±5.97 mg/L unopposed) compared to transdermal HT users (2.65±4.44 mg/L). CRP increased slightly (p=0.077) in exercisers (0.54 ± 0.34 mg/L) not taking HT compared to controls (-0.39 ± 0.35 mg/L). Reductions in TFM were associated with reductions in IL-6 and CRP in HT users. CK was positively associated to all BMD sites at baseline. IL-6 change was positively associated with change in femur neck BMD. CRP change was inversely correlated with change in lumbar spine BMD. CK change was directly related to change in total body and femur trochanter BMD. In conclusion, reductions in TFM were accompanied by reductions in IL-6 and CRP; AFM was more strongly correlated with inflammation than TFM; 12-months of resistance training did not decrease IL-6 or CRP; IL-6 and CK were positively related to BMD, and CRP was inversely associated with BMD.
Type:
text; Electronic Dissertation
Keywords:
C-reactive protein; Interleukin-6; resistance training; postmenopausal women; bone mineral density; body composition
Degree Name:
PhD
Degree Level:
doctoral
Degree Program:
Physiological Sciences; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Lohman, Timothy G.
Committee Chair:
Lohman, Timothy G.

Full metadata record

DC FieldValue Language
dc.language.isoENen_US
dc.titleRESISTANCE TRAINING AND MEASURES OF INFLAMMATION IN RELATION TO BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMENen_US
dc.creatorStanescu, Claudia Ioanaen_US
dc.contributor.authorStanescu, Claudia Ioanaen_US
dc.date.issued2005en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe purpose of this study was to determine the role of body composition and fat distribution on C-reactive protein (CRP) and interleukin-6 (IL-6); determine the differences in CRP and IL-6 among HT users and non-users; determine the effect of 12-months of resistance training and resulting body composition changes on IL-6 and CRP; determine the relationship between BMD and IL-6, CRP and creatine kinase (CK). Sedentary women (N=208, age 44-66, 3-10 years postmenopausal) taking HT (N=106) or not taking HT (N=102) were randomly assigned to resistance training: HTexercise (N=55), HT-no exercise (N=45), no HT-exercise (N=53), and no HT-no exercise (N=49). The program included three weekly 60-75 minute sessions of 8 exercises performed in 2 sets of 6-8 repetitions at 70-80% of 1RM. Total fat mass (TFM), lean soft tissue mass (LSTM) and BMD were assessed by dual-energy X-ray absorptiometry (DXA). Abdominal fat mass (AFM) was assessed using DXA region of interest. For each subject, baseline and 1- year IL-6, CRP and CK were measured. High TFM, high IL-6 and HT use were independently associated with high CRP levels. A stronger relationship between IL-6 and AFM compared to TFM was found in HT users. High TFM and LSTM were significantly related to higher IL-6 levels. A stronger relationship between CRP and AFM compared to TFM was found in HT non-users. CRP was higher in HT users (5.47±5.40 mg/L) compared to non-users (2.70±3.05 mg/L) and was higher in oral (5.76±5.29 mg/L opposed; 6.14±5.97 mg/L unopposed) compared to transdermal HT users (2.65±4.44 mg/L). CRP increased slightly (p=0.077) in exercisers (0.54 ± 0.34 mg/L) not taking HT compared to controls (-0.39 ± 0.35 mg/L). Reductions in TFM were associated with reductions in IL-6 and CRP in HT users. CK was positively associated to all BMD sites at baseline. IL-6 change was positively associated with change in femur neck BMD. CRP change was inversely correlated with change in lumbar spine BMD. CK change was directly related to change in total body and femur trochanter BMD. In conclusion, reductions in TFM were accompanied by reductions in IL-6 and CRP; AFM was more strongly correlated with inflammation than TFM; 12-months of resistance training did not decrease IL-6 or CRP; IL-6 and CK were positively related to BMD, and CRP was inversely associated with BMD.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.subjectC-reactive proteinen_US
dc.subjectInterleukin-6en_US
dc.subjectresistance trainingen_US
dc.subjectpostmenopausal womenen_US
dc.subjectbone mineral densityen_US
dc.subjectbody compositionen_US
thesis.degree.namePhDen_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplinePhysiological Sciencesen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorLohman, Timothy G.en_US
dc.contributor.chairLohman, Timothy G.en_US
dc.contributor.committeememberGoing, Scott B.en_US
dc.contributor.committeememberWilliams, Daniel P.en_US
dc.contributor.committeememberHenriksen, Eriken_US
dc.contributor.committeememberThomson, Cynthiaen_US
dc.identifier.proquest1230en_US
dc.identifier.oclc137354495en_US
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