High-resolution Diffusion-weighted Magnetic Resonance Imaging: Development and Application of Novel Radial Fast Spin-echo Acquisitions

Persistent Link:
http://hdl.handle.net/10150/194624
Title:
High-resolution Diffusion-weighted Magnetic Resonance Imaging: Development and Application of Novel Radial Fast Spin-echo Acquisitions
Author:
Sarlls, Joelle Elita
Issue Date:
2006
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Diffusion-weighted Magnetic Resonance Imaging (DWI) has become a useful tool in medicine for the purpose of diagnosis, tracking disease progression, and monitoring response to therapy. The current techniques used for DWI suffer from artifacts due to magnetic field inhomogeneities, image distortion, and low spatial resolution. The aim of the presented work is to advance DWI by improving upon and developing novel high-resolution acquisition techniques. The approach taken for this purpose was to utilize radial fast spin-echo data acquisitions, which have been shown to produce high-resolution DWI without artifacts due to magnetic field inhomogeneities. In addition, there is little image distortion in radial fast spin-echo DWI, which allows for direct overlay onto anatomical MRI. However, a draw back is that radial methods require longer scan times. By increasing the imaging speed of existing radial fast spin-echo acquisitions, it may become a more practical clinical tool. In addition, novel acquisition techniques are developed that push high-resolution to all three dimensions. By employing a three-dimensional radial fast spin-echo acquisition, voxels in an image have equal size in each dimension and can be on the order of 1mm3. By decreasing the voxel size, the tissue contained within a voxel is more homogeneous. This is important for DWI applications that aim to measure the microscopic integrity of the tissue. The development and analysis of the novel radial fast spin-echo techniques are presented in this work along with several clinical applications. The remaining issues to be addressed for application to quantitative DWI measures are also presented, along with possible solutions.
Type:
text; Electronic Dissertation
Keywords:
Biomedical Engineering
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Biomedical Engineering; Graduate College
Degree Grantor:
University of Arizona
Committee Chair:
Trouard, Theodore P.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleHigh-resolution Diffusion-weighted Magnetic Resonance Imaging: Development and Application of Novel Radial Fast Spin-echo Acquisitionsen_US
dc.creatorSarlls, Joelle Elitaen_US
dc.contributor.authorSarlls, Joelle Elitaen_US
dc.date.issued2006en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractDiffusion-weighted Magnetic Resonance Imaging (DWI) has become a useful tool in medicine for the purpose of diagnosis, tracking disease progression, and monitoring response to therapy. The current techniques used for DWI suffer from artifacts due to magnetic field inhomogeneities, image distortion, and low spatial resolution. The aim of the presented work is to advance DWI by improving upon and developing novel high-resolution acquisition techniques. The approach taken for this purpose was to utilize radial fast spin-echo data acquisitions, which have been shown to produce high-resolution DWI without artifacts due to magnetic field inhomogeneities. In addition, there is little image distortion in radial fast spin-echo DWI, which allows for direct overlay onto anatomical MRI. However, a draw back is that radial methods require longer scan times. By increasing the imaging speed of existing radial fast spin-echo acquisitions, it may become a more practical clinical tool. In addition, novel acquisition techniques are developed that push high-resolution to all three dimensions. By employing a three-dimensional radial fast spin-echo acquisition, voxels in an image have equal size in each dimension and can be on the order of 1mm3. By decreasing the voxel size, the tissue contained within a voxel is more homogeneous. This is important for DWI applications that aim to measure the microscopic integrity of the tissue. The development and analysis of the novel radial fast spin-echo techniques are presented in this work along with several clinical applications. The remaining issues to be addressed for application to quantitative DWI measures are also presented, along with possible solutions.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.subjectBiomedical Engineeringen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineBiomedical Engineeringen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.chairTrouard, Theodore P.en_US
dc.contributor.committeememberGmitro, Arthuren_US
dc.contributor.committeememberDallas, Williamen_US
dc.contributor.committeememberAltbach, Maria I.en_US
dc.identifier.proquest1704en_US
dc.identifier.oclc137356787en_US
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