Formation of Dicentric and Acentric Chromosomes, by a Template Switch Mechanism, in Budding Yeast

Persistent Link:
http://hdl.handle.net/10150/194260
Title:
Formation of Dicentric and Acentric Chromosomes, by a Template Switch Mechanism, in Budding Yeast
Author:
Paek, Andrew Luther
Issue Date:
2010
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Chromosomal rearrangements occur in all organisms and are important both in the evolution of species and in pathology. In this dissertation I show that in Saccharomyces cerevisiae, or budding yeast, one type of chromosomal rearrangement occurs when inverted repeats fuse, likely during DNA replication by a novel mechanism termed "faulty template switching". This fusion can lead to the formation of either a dicentric or acentric chromosome, depending on the direction of the replication fork. Dicentric chromosomes are inherently unstable due to their abnormal number of centromeres, and thus undergo additional chromosomal rearrangements and chromosome loss.
Type:
text; Electronic Dissertation
Keywords:
Acentric Chromosomes; Budding Yeast; Dicentric Chromosomes; Genome Instability; Inverted Repeats; Template Switching
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Molecular & Cellular Biology; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Weinert, Ted
Committee Chair:
Weinert, Ted

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleFormation of Dicentric and Acentric Chromosomes, by a Template Switch Mechanism, in Budding Yeasten_US
dc.creatorPaek, Andrew Lutheren_US
dc.contributor.authorPaek, Andrew Lutheren_US
dc.date.issued2010en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractChromosomal rearrangements occur in all organisms and are important both in the evolution of species and in pathology. In this dissertation I show that in Saccharomyces cerevisiae, or budding yeast, one type of chromosomal rearrangement occurs when inverted repeats fuse, likely during DNA replication by a novel mechanism termed "faulty template switching". This fusion can lead to the formation of either a dicentric or acentric chromosome, depending on the direction of the replication fork. Dicentric chromosomes are inherently unstable due to their abnormal number of centromeres, and thus undergo additional chromosomal rearrangements and chromosome loss.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.subjectAcentric Chromosomesen_US
dc.subjectBudding Yeasten_US
dc.subjectDicentric Chromosomesen_US
dc.subjectGenome Instabilityen_US
dc.subjectInverted Repeatsen_US
dc.subjectTemplate Switchingen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineMolecular & Cellular Biologyen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorWeinert, Teden_US
dc.contributor.chairWeinert, Teden_US
dc.contributor.committeememberDixon, Kathleenen_US
dc.contributor.committeememberLittle, Johnen_US
dc.contributor.committeememberNagy, Lisaen_US
dc.identifier.proquest11295en_US
dc.identifier.oclc752261140en_US
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.