Evolution of Sporulation in Bacillus Subtilis: Functional Loss and Evolutionary Consequences

Persistent Link:
http://hdl.handle.net/10150/193989
Title:
Evolution of Sporulation in Bacillus Subtilis: Functional Loss and Evolutionary Consequences
Author:
Maughan, Heather
Issue Date:
2006
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The loss of phenotypes, a phenomenon capable of leading to ecological specialization, has been observed to occur readily during evolution and is an important contributor to the phenotypic variation observed in nature. While the loss of phenotypes is often observed, the population genetic processes responsible for phenotypic loss are not well understood. This lack of understanding is due to the complexity of evolutionary process and the intricacy of how information from the genotype develops into the phenotype. The work presented in this dissertation is a first attempt to disentangle the complexity of the population genetics of trait loss in experimental populations of Bacillus subtilis, a bacterium of the low G+C Gram positive group. The experiments described in this dissertation showed that the deletion of two complex phenotypes occurred throughout evolutionary time. While there is evidence suggesting that this phenotypic loss may be due to trade-offs between traits that were lost and those important for fitness, i.e. selection, the contribution of neutral mutation accumulation cannot be ruled out. Genomic studies identified candidate expression changes potentially able to explain the observed phenotypic loss, paving the way for future work linking the observed phenotypic changes with their underlying genetic and developmental cause(s). The results from this dissertation work speak to the complexity of trait loss and the difficulty of explicitly determining whether selective or neutral processes are responsible for trait loss in nature.
Type:
text; Electronic Dissertation
Degree Name:
PhD
Degree Level:
doctoral
Degree Program:
Ecology & Evolutionary Biology; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Nicholson, Wayne L.; Birky Jr., C. William
Committee Chair:
Birky Jr., C. William

Full metadata record

DC FieldValue Language
dc.language.isoENen_US
dc.titleEvolution of Sporulation in Bacillus Subtilis: Functional Loss and Evolutionary Consequencesen_US
dc.creatorMaughan, Heatheren_US
dc.contributor.authorMaughan, Heatheren_US
dc.date.issued2006en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe loss of phenotypes, a phenomenon capable of leading to ecological specialization, has been observed to occur readily during evolution and is an important contributor to the phenotypic variation observed in nature. While the loss of phenotypes is often observed, the population genetic processes responsible for phenotypic loss are not well understood. This lack of understanding is due to the complexity of evolutionary process and the intricacy of how information from the genotype develops into the phenotype. The work presented in this dissertation is a first attempt to disentangle the complexity of the population genetics of trait loss in experimental populations of Bacillus subtilis, a bacterium of the low G+C Gram positive group. The experiments described in this dissertation showed that the deletion of two complex phenotypes occurred throughout evolutionary time. While there is evidence suggesting that this phenotypic loss may be due to trade-offs between traits that were lost and those important for fitness, i.e. selection, the contribution of neutral mutation accumulation cannot be ruled out. Genomic studies identified candidate expression changes potentially able to explain the observed phenotypic loss, paving the way for future work linking the observed phenotypic changes with their underlying genetic and developmental cause(s). The results from this dissertation work speak to the complexity of trait loss and the difficulty of explicitly determining whether selective or neutral processes are responsible for trait loss in nature.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
thesis.degree.namePhDen_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineEcology & Evolutionary Biologyen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorNicholson, Wayne L.en_US
dc.contributor.advisorBirky Jr., C. Williamen_US
dc.contributor.chairBirky Jr., C. Williamen_US
dc.contributor.committeememberBirky Jr., C. Williamen_US
dc.contributor.committeememberMoran, Nancy A.en_US
dc.contributor.committeememberNachman, Michael W.en_US
dc.contributor.committeememberPierson III, Leland S.en_US
dc.identifier.proquest1483en_US
dc.identifier.oclc659746256en_US
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