Persistent Link:
http://hdl.handle.net/10150/193829
Title:
Novel Body Magnetic Resonance Imaging Techniques
Author:
Li, Zhiqiang
Issue Date:
2006
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Body magnetic resonance imaging (MRI) has progressed rapidly over the last 12 years. The advances in hardware and software have allowed the implementation of faster and better pulse sequences for body imaging. Despite the improvements in MRI technology there are still problems associated with current body MRI techniques that limit their diagnostic capabilities. The main goal of this work is to develop novel body MRI methods to improve the diagnosis of cardiac and abdominal pathologies. One of the goals of this work is to develop a technique to improve the detection of lipid infiltration in the heart. For this purpose an interleaved double-inversion fast spin-echo technique was developed. The method yields co-registered lipid and water images of the heart from data acquired in a single breath hold, producing data with optimal contrast between lipid and myocardium as well as minimal artifacts caused by chemical shift and blood flow.A technique combining GRAdient and Spin-Echo (GRASE) data acquisition and an iterative algorithm for lipid-water separation (Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation, IDEAL) was also developed. By shifting the typical GRASE data acquisition and employing correction for phase errors due to eddy currents, the IDEAL-GRASE technique achieves more time-efficient and robust lipid-water decomposition in the presence of field inhomogeneities. The technique was developed to acquire data for Cartesian and radial k-space trajectories. The radial IDEAL-GRASE with auto-correction of phase errors was developed to accomplish insensitivity to motion artifacts as well as for the generation of high resolution parametric maps (T2 and T2) for tissue characterization.A radial "variable flip angle" Steady-State Free Precession (SSFP) technique with slice profile correction was also developed to obtain fast estimation of another parameter, i.e. the T1/T2 value. This method was developed as an alternative for fast parametric imaging.These body MRI techniques were evaluated in phantoms, healthy volunteers, and patients and demonstrated for a series of applications including pelvic, cardiac, abdominal, and musculoskeletal imaging.
Type:
text; Electronic Dissertation
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Electrical & Computer Engineering; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Altbach, Maria I.; Gmitro, Arthur F.
Committee Chair:
Marcellin, Michael W.; Altbach, Maria I.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleNovel Body Magnetic Resonance Imaging Techniquesen_US
dc.creatorLi, Zhiqiangen_US
dc.contributor.authorLi, Zhiqiangen_US
dc.date.issued2006en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractBody magnetic resonance imaging (MRI) has progressed rapidly over the last 12 years. The advances in hardware and software have allowed the implementation of faster and better pulse sequences for body imaging. Despite the improvements in MRI technology there are still problems associated with current body MRI techniques that limit their diagnostic capabilities. The main goal of this work is to develop novel body MRI methods to improve the diagnosis of cardiac and abdominal pathologies. One of the goals of this work is to develop a technique to improve the detection of lipid infiltration in the heart. For this purpose an interleaved double-inversion fast spin-echo technique was developed. The method yields co-registered lipid and water images of the heart from data acquired in a single breath hold, producing data with optimal contrast between lipid and myocardium as well as minimal artifacts caused by chemical shift and blood flow.A technique combining GRAdient and Spin-Echo (GRASE) data acquisition and an iterative algorithm for lipid-water separation (Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation, IDEAL) was also developed. By shifting the typical GRASE data acquisition and employing correction for phase errors due to eddy currents, the IDEAL-GRASE technique achieves more time-efficient and robust lipid-water decomposition in the presence of field inhomogeneities. The technique was developed to acquire data for Cartesian and radial k-space trajectories. The radial IDEAL-GRASE with auto-correction of phase errors was developed to accomplish insensitivity to motion artifacts as well as for the generation of high resolution parametric maps (T2 and T2) for tissue characterization.A radial "variable flip angle" Steady-State Free Precession (SSFP) technique with slice profile correction was also developed to obtain fast estimation of another parameter, i.e. the T1/T2 value. This method was developed as an alternative for fast parametric imaging.These body MRI techniques were evaluated in phantoms, healthy volunteers, and patients and demonstrated for a series of applications including pelvic, cardiac, abdominal, and musculoskeletal imaging.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineElectrical & Computer Engineeringen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorAltbach, Maria I.en_US
dc.contributor.advisorGmitro, Arthur F.en_US
dc.contributor.chairMarcellin, Michael W.en_US
dc.contributor.chairAltbach, Maria I.en_US
dc.contributor.committeememberMarcellin, Michael W.en_US
dc.contributor.committeememberAltbach, Maria I.en_US
dc.contributor.committeememberGmitro, Arthur F.en_US
dc.contributor.committeememberBilgin, Alien_US
dc.contributor.committeememberUtzinger, Ursen_US
dc.identifier.proquest1838en_US
dc.identifier.oclc659746383en_US
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