Persistent Link:
http://hdl.handle.net/10150/193732
Title:
Preformulation Studies on the Anticancer Drug Imexon
Author:
Kuehl, Philip
Issue Date:
2007
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Imexon is an aziridine-containing iminopyrrolidone that is of significant interest due to its selective growth inhibitory effect against multiple myeloma. Regrettably, administration of Imexon has proven difficult largely due to its rapid degradation in aqueous medium. The collective aim of this research was to conduct preformulation studies to characterize and understand the stability and solubility of Imexon in both aqueous and non-aqueous systems. Furthermore, these data will be utilized as rational support to create an efficacious formulation for the delivery of Imexon.
Type:
text; Electronic Dissertation
Degree Name:
PhD
Degree Level:
doctoral
Degree Program:
Pharmaceutical Sciences; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Myrdal, Paul B
Committee Chair:
Myrdal, Paul B

Full metadata record

DC FieldValue Language
dc.language.isoENen_US
dc.titlePreformulation Studies on the Anticancer Drug Imexonen_US
dc.creatorKuehl, Philipen_US
dc.contributor.authorKuehl, Philipen_US
dc.date.issued2007en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractImexon is an aziridine-containing iminopyrrolidone that is of significant interest due to its selective growth inhibitory effect against multiple myeloma. Regrettably, administration of Imexon has proven difficult largely due to its rapid degradation in aqueous medium. The collective aim of this research was to conduct preformulation studies to characterize and understand the stability and solubility of Imexon in both aqueous and non-aqueous systems. Furthermore, these data will be utilized as rational support to create an efficacious formulation for the delivery of Imexon.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
thesis.degree.namePhDen_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplinePharmaceutical Sciencesen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorMyrdal, Paul Ben_US
dc.contributor.chairMyrdal, Paul Ben_US
dc.contributor.committeememberMayersohn, Michaelen_US
dc.contributor.committeememberYalkowsky, Samuel H.en_US
dc.identifier.proquest1999en_US
dc.identifier.oclc659746593en_US
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.