Persistent Link:
http://hdl.handle.net/10150/193711
Title:
Source Memory and Frontal Functioning in Parkinson's Disease
Author:
Kong, Lauren
Issue Date:
2008
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopamine dysregulation in several regions of the brain, including the striatum. Because of the intimate connections between the striatum and the frontal lobes, individuals with PD often demonstrate impairments on those tasks relying on the prefrontal cortex (e.g. tests of executive functioning). Source memory, or memory for context, is believed to rely on the prefrontal cortex and has been previously associated with executive functioning performance, although it has received little attention in the PD literature. Executive functioning and source memory were measured in a group of non-demented PD patients and healthy control participants. Within the PD group, an anti-Parkinson's medication withdrawal manipulation was used to examine whether source memory was affected by phasic changes in dopamine levels. Compared to healthy control participants, PD patients were impaired in source memory (both on and off medication) and on two composite measures of executive functioning. Within the PD group, medication administration improved motor performance but did not have a significant effect on source memory, suggesting that source memory may not rely on the dopamine system.
Type:
text; Electronic Dissertation
Keywords:
Parkinson's Disease; Memory; Source Memory; Executive Functioning; Planning
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Psychology; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Glisky, Elizabeth L.; Allen, John J.B.
Committee Chair:
Glisky, Elizabeth L.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleSource Memory and Frontal Functioning in Parkinson's Diseaseen_US
dc.creatorKong, Laurenen_US
dc.contributor.authorKong, Laurenen_US
dc.date.issued2008en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractParkinson's disease (PD) is a neurodegenerative disorder characterized by dopamine dysregulation in several regions of the brain, including the striatum. Because of the intimate connections between the striatum and the frontal lobes, individuals with PD often demonstrate impairments on those tasks relying on the prefrontal cortex (e.g. tests of executive functioning). Source memory, or memory for context, is believed to rely on the prefrontal cortex and has been previously associated with executive functioning performance, although it has received little attention in the PD literature. Executive functioning and source memory were measured in a group of non-demented PD patients and healthy control participants. Within the PD group, an anti-Parkinson's medication withdrawal manipulation was used to examine whether source memory was affected by phasic changes in dopamine levels. Compared to healthy control participants, PD patients were impaired in source memory (both on and off medication) and on two composite measures of executive functioning. Within the PD group, medication administration improved motor performance but did not have a significant effect on source memory, suggesting that source memory may not rely on the dopamine system.en_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectMemoryen_US
dc.subjectSource Memoryen_US
dc.subjectExecutive Functioningen_US
dc.subjectPlanningen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplinePsychologyen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorGlisky, Elizabeth L.en_US
dc.contributor.advisorAllen, John J.B.en_US
dc.contributor.chairGlisky, Elizabeth L.en_US
dc.contributor.committeememberKaszniak, Alfred W.en_US
dc.contributor.committeememberAllen, John J.B.en_US
dc.contributor.committeememberRapcsak, Steveen_US
dc.contributor.committeememberBieliauskas, Linasen_US
dc.identifier.proquest2770en_US
dc.identifier.oclc659749802en_US
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