Repeatability of Sample Collection Methods Among Men from the HPV Detection in Asymptomatic Men Study

Persistent Link:
http://hdl.handle.net/10150/193383
Title:
Repeatability of Sample Collection Methods Among Men from the HPV Detection in Asymptomatic Men Study
Author:
Abalos, Andrew T.
Issue Date:
2006
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
HPV prevalence in men varies across populations and with different sampling methods. However, reliability of sampling methods in men is unknown. The goal of this study is to assess repeatability of HPV sampling among asymptomatic men. Duplicate swab samples were collected at five anogenital sites from 139 men from the HPV Detection in Asymptomatic Men study in 2005. HPV testing by PCR and reverse line blot genotyping for 37 HPV types was conducted on each sample independently. Anatomic site-specific HPV prevalence, concordance and Kappa statistics were calculated for any HPV, oncogenic types, and nononcogenic types. Site-specific HPV prevalence was highest at the penile shaft among detectable HPV types. Agreement was consistently observed to be the highest at the penile shaft and coronal sulcus/glans penis. No consistent predictors of discordance were identified. These results show high levels of repeatability in our HPV sampling methods.
Type:
text; Electronic Thesis
Degree Name:
MS
Degree Level:
masters
Degree Program:
Epidemiology; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Harris, Robin B.
Committee Chair:
Harris, Robin B.

Full metadata record

DC FieldValue Language
dc.language.isoENen_US
dc.titleRepeatability of Sample Collection Methods Among Men from the HPV Detection in Asymptomatic Men Studyen_US
dc.creatorAbalos, Andrew T.en_US
dc.contributor.authorAbalos, Andrew T.en_US
dc.date.issued2006en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractHPV prevalence in men varies across populations and with different sampling methods. However, reliability of sampling methods in men is unknown. The goal of this study is to assess repeatability of HPV sampling among asymptomatic men. Duplicate swab samples were collected at five anogenital sites from 139 men from the HPV Detection in Asymptomatic Men study in 2005. HPV testing by PCR and reverse line blot genotyping for 37 HPV types was conducted on each sample independently. Anatomic site-specific HPV prevalence, concordance and Kappa statistics were calculated for any HPV, oncogenic types, and nononcogenic types. Site-specific HPV prevalence was highest at the penile shaft among detectable HPV types. Agreement was consistently observed to be the highest at the penile shaft and coronal sulcus/glans penis. No consistent predictors of discordance were identified. These results show high levels of repeatability in our HPV sampling methods.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameMSen_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineEpidemiologyen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorHarris, Robin B.en_US
dc.contributor.chairHarris, Robin B.en_US
dc.identifier.proquest1989en_US
dc.identifier.oclc659746588en_US
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