Persistent Link:
http://hdl.handle.net/10150/193380
Title:
Physical Activity as a Determinant of Fecal Bile Acid Levels
Author:
Wertheim, Betsy Chaitkin
Issue Date:
2008
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Physical activity is protective against colon cancer, whereas colonic bile acid exposure is considered a risk factor. However, the relationship between physical activity and bile acid levels has not been well studied. A cross-sectional analysis of fecal bile acid levels was conducted for 735 colorectal adenoma formers of the ursodeoxycholic acid chemoprevention trial. Hours of recreational activity was found to be inversely related to total fecal bile acid concentrations among participants with low triglycerides, but not for those with high triglycerides. The distinct effects of physical activity between individuals with low versus high triglycerides are suggested to be related to changes in bile acid metabolism, as people with high triglycerides are more likely to have impaired bile acid absorption, thereby increasing bile acid excretion. These results suggest that the protective effect of physical activity may be mediated through decreased colonic bile acid exposure, but only in individuals with low triglycerides.
Type:
text; Electronic Thesis
Degree Name:
MS
Degree Level:
masters
Degree Program:
Epidemiology; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Martinez, Maria E; Thompson, Patricia A
Committee Chair:
Martinez, Maria E

Full metadata record

DC FieldValue Language
dc.language.isoENen_US
dc.titlePhysical Activity as a Determinant of Fecal Bile Acid Levelsen_US
dc.creatorWertheim, Betsy Chaitkinen_US
dc.contributor.authorWertheim, Betsy Chaitkinen_US
dc.date.issued2008en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractPhysical activity is protective against colon cancer, whereas colonic bile acid exposure is considered a risk factor. However, the relationship between physical activity and bile acid levels has not been well studied. A cross-sectional analysis of fecal bile acid levels was conducted for 735 colorectal adenoma formers of the ursodeoxycholic acid chemoprevention trial. Hours of recreational activity was found to be inversely related to total fecal bile acid concentrations among participants with low triglycerides, but not for those with high triglycerides. The distinct effects of physical activity between individuals with low versus high triglycerides are suggested to be related to changes in bile acid metabolism, as people with high triglycerides are more likely to have impaired bile acid absorption, thereby increasing bile acid excretion. These results suggest that the protective effect of physical activity may be mediated through decreased colonic bile acid exposure, but only in individuals with low triglycerides.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameMSen_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineEpidemiologyen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorMartinez, Maria Een_US
dc.contributor.advisorThompson, Patricia Aen_US
dc.contributor.chairMartinez, Maria Een_US
dc.identifier.proquest2862en_US
dc.identifier.oclc659749528en_US
All Items in UA Campus Repository are protected by copyright, with all rights reserved, unless otherwise indicated.