The Role Of The Small GTPASE RAB14 In Apical ProteinTraffic And Maintenance Of Cell Polarity

Persistent Link:
http://hdl.handle.net/10150/193346
Title:
The Role Of The Small GTPASE RAB14 In Apical ProteinTraffic And Maintenance Of Cell Polarity
Author:
Jacobson, Noelle C
Issue Date:
2005
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The establishment and maintenance of cell polarity during development is an active process that requires specific protein sorting and targeting to apical and basolateral regions of the cell. Our lab has identified an apical early endosomal marker, endotubin, in developing rat intestine, which we have used to label specialized apical endosomal tubules, and to probe for components of the apical sorting machinery. Studies with endotubin have implicated the small GTPase Rab14 as part of the sorting machinery for apical targeting. The current work pursues further study of the interaction between Rab14 and endotubin, as well as the role for Rab14 in the establishment of cell asymmetry. Interestingly, even nonpolarized cells may utilize polarized trafficking components for proper sorting and dynamics of endotubin.
Type:
text; Electronic Thesis
Keywords:
protein trafficking; cell polarity; apical protein sorting; membrane trafficking; epithelial polarity
Degree Name:
MS
Degree Level:
masters
Degree Program:
Cell Biology & Anatomy; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Wilson, Jean M.
Committee Chair:
Wilson, Jean M.

Full metadata record

DC FieldValue Language
dc.language.isoENen_US
dc.titleThe Role Of The Small GTPASE RAB14 In Apical ProteinTraffic And Maintenance Of Cell Polarityen_US
dc.creatorJacobson, Noelle Cen_US
dc.contributor.authorJacobson, Noelle Cen_US
dc.date.issued2005en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe establishment and maintenance of cell polarity during development is an active process that requires specific protein sorting and targeting to apical and basolateral regions of the cell. Our lab has identified an apical early endosomal marker, endotubin, in developing rat intestine, which we have used to label specialized apical endosomal tubules, and to probe for components of the apical sorting machinery. Studies with endotubin have implicated the small GTPase Rab14 as part of the sorting machinery for apical targeting. The current work pursues further study of the interaction between Rab14 and endotubin, as well as the role for Rab14 in the establishment of cell asymmetry. Interestingly, even nonpolarized cells may utilize polarized trafficking components for proper sorting and dynamics of endotubin.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
dc.subjectprotein traffickingen_US
dc.subjectcell polarityen_US
dc.subjectapical protein sortingen_US
dc.subjectmembrane traffickingen_US
dc.subjectepithelial polarityen_US
thesis.degree.nameMSen_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineCell Biology & Anatomyen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorWilson, Jean M.en_US
dc.contributor.chairWilson, Jean M.en_US
dc.identifier.proquest1263en_US
dc.identifier.oclc137354687en_US
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