PROGRESS TOWARDS A SYNTHESIS OF DEOXYBOUVARDIN AND ANALOGUES; NEW SYNTHETIC METHODS.

Persistent Link:
http://hdl.handle.net/10150/187884
Title:
PROGRESS TOWARDS A SYNTHESIS OF DEOXYBOUVARDIN AND ANALOGUES; NEW SYNTHETIC METHODS.
Author:
JANDA, KIM DAVID.
Issue Date:
1984
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
This work involved synthetic approaches to the anti-tumor agent deoxybouvardin. Numerous reactions were explored in an attempt to build an amino acid from an aromatic aldehyde under mild conditions. From these reactions new and useful synthetic methods have been discovered for making α-acylamino alcohols and unsymmetrical imides. Some dehydroamino acids were successfully prepared from aromatic aldehydes and an N-acylphosphorylglycine ester. Progress towards a synthesis of 5- η-thiodeoxybouvardin will also be discussed.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Amino acids -- Synthesis.; Organic compounds -- Synthesis.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Chemistry; Graduate College
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titlePROGRESS TOWARDS A SYNTHESIS OF DEOXYBOUVARDIN AND ANALOGUES; NEW SYNTHETIC METHODS.en_US
dc.creatorJANDA, KIM DAVID.en_US
dc.contributor.authorJANDA, KIM DAVID.en_US
dc.date.issued1984en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThis work involved synthetic approaches to the anti-tumor agent deoxybouvardin. Numerous reactions were explored in an attempt to build an amino acid from an aromatic aldehyde under mild conditions. From these reactions new and useful synthetic methods have been discovered for making α-acylamino alcohols and unsymmetrical imides. Some dehydroamino acids were successfully prepared from aromatic aldehydes and an N-acylphosphorylglycine ester. Progress towards a synthesis of 5- η-thiodeoxybouvardin will also be discussed.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectAmino acids -- Synthesis.en_US
dc.subjectOrganic compounds -- Synthesis.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.identifier.proquest8505232en_US
dc.identifier.oclc693569290en_US
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