NEUROPHARMACOLOGICAL INVESTIGATION OF VASOPRESSIN, A PUTATIVE MEMORY NEURAL PEPTIDE (NEUROPEPTIDE, NEUROHYPOPHYSENE, HORMONES).

Persistent Link:
http://hdl.handle.net/10150/187822
Title:
NEUROPHARMACOLOGICAL INVESTIGATION OF VASOPRESSIN, A PUTATIVE MEMORY NEURAL PEPTIDE (NEUROPEPTIDE, NEUROHYPOPHYSENE, HORMONES).
Author:
BRINTON, ROBERTA EILEEN.
Issue Date:
1984
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Vasopressin, or antidiurectic hormone, has long been known to have peripheral antidiuretic and vasoconstrictor properties. However, more recently a body of research has shown that vasopressin (AVP) affects central nervous system functions by to influencing memory processes. In light of the growing evidence for the role of vasopressin (AVP) in memory, my dissertation research was designed to test the hypothesis that AVP acts as a neuromodulator in the CNS. To test this hypothesis criteria used to establish neurotransmitter status was applied to AVP. Thus, a series of experiments were carried out to investigate (1) AVP brain levels; (2) release of AVP in the CNS; (3) existence of specific AVP binding sites in brain and finally, (4) existence of AVP metabolite peptide, AVP (4-9), binding sites in brain. Results of these experiments indicate that AVP meets some of the criteria for neuromodulator status in the CNS. The detection of AVP in brain, elucidation of the modulatory influence of a CNS depressant upon the content and release of AVP in brain, demonstration and characterization of the regional distribution for putative AVP receptors in brain along with binding sites for a metabolite peptide of AVP, all suggest that AVP acts through receptors within the CNS to influence memory processes.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Neuropharmacology.; Neuropsychopharmacology.; Psychophysiology.; Vasopressin.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Psychology; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Yamamura, Henry I.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleNEUROPHARMACOLOGICAL INVESTIGATION OF VASOPRESSIN, A PUTATIVE MEMORY NEURAL PEPTIDE (NEUROPEPTIDE, NEUROHYPOPHYSENE, HORMONES).en_US
dc.creatorBRINTON, ROBERTA EILEEN.en_US
dc.contributor.authorBRINTON, ROBERTA EILEEN.en_US
dc.date.issued1984en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractVasopressin, or antidiurectic hormone, has long been known to have peripheral antidiuretic and vasoconstrictor properties. However, more recently a body of research has shown that vasopressin (AVP) affects central nervous system functions by to influencing memory processes. In light of the growing evidence for the role of vasopressin (AVP) in memory, my dissertation research was designed to test the hypothesis that AVP acts as a neuromodulator in the CNS. To test this hypothesis criteria used to establish neurotransmitter status was applied to AVP. Thus, a series of experiments were carried out to investigate (1) AVP brain levels; (2) release of AVP in the CNS; (3) existence of specific AVP binding sites in brain and finally, (4) existence of AVP metabolite peptide, AVP (4-9), binding sites in brain. Results of these experiments indicate that AVP meets some of the criteria for neuromodulator status in the CNS. The detection of AVP in brain, elucidation of the modulatory influence of a CNS depressant upon the content and release of AVP in brain, demonstration and characterization of the regional distribution for putative AVP receptors in brain along with binding sites for a metabolite peptide of AVP, all suggest that AVP acts through receptors within the CNS to influence memory processes.en_US
dc.description.noteDigitization note: p. 55 missing from paper original.-
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectNeuropharmacology.en_US
dc.subjectNeuropsychopharmacology.en_US
dc.subjectPsychophysiology.en_US
dc.subjectVasopressin.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplinePsychologyen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorYamamura, Henry I.en_US
dc.contributor.committeememberBurks, Thomasen_US
dc.contributor.committeememberLansing, Roberten_US
dc.contributor.committeememberWarner, Susanen_US
dc.identifier.proquest8504114en_US
dc.identifier.oclc693389000en_US
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