METABOLISM OF 2,2, - BIS (P-CHLOROPHENYL)-1, 1-DICHLOROETHYLENE (DDE) BY THE BOVINE.

Persistent Link:
http://hdl.handle.net/10150/187753
Title:
METABOLISM OF 2,2, - BIS (P-CHLOROPHENYL)-1, 1-DICHLOROETHYLENE (DDE) BY THE BOVINE.
Author:
MOHAMMAD, KASSIM HASSAN.
Issue Date:
1984
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Twelve lactating Holstein dairy cows were randomly divided into four groups of three animals each. Group A served as the control, group B was dosed at 0.05ppm/day of DDE (2,2-bis(P-chlorophenyl-1, 1-dichloroethylene), cows in group C were dosed at 0.1ppm DDE/day, while group D cows were dosed at 1.0ppm DDE/day. DDE was administered in a residue free peanut oil solution for 32-consecutive days. Milk samples were taken daily during the 32 day dosing period and for an additional 32 days after the dosing period. Quantitative analysis of DDE residue in milk fat was determined by using a Tracor MT-220 gas chromatograph with a Tritium electron capture detector. The average increase in DDE milk fat concentration during the dosing period was directly related to intake levels. DDE was the only organochlorine compound detected in the milk fat. The general slope and shape of the curves of milk fat DDE levels were similar for all treatments. The levels of DDE increased rapidly after the onset of dosing. After 15 days of dosing and throughout the remaining 17 days of the dosing period, milk fat DDE increased at a relatively slow rate. The level of milk fat DDE declined rapidly as soon as the DDE residue source was withdrawn. At the end of the 32-day post-dosing period, one cow from each group was slaughtered and samples were taken from muscles, brain, lung, lymph, spleen, kidney fat, heart, gonad, placenta, udder, and kidney for DDE analysis. Considerable DDE was found in the muscle, lymph, kidney fat, and udder tissues.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Ethylene compounds -- Metabolism.; Publisher 1984.; Milk contamination.; Organochlorine compounds -- Metabolism.; DDT (Insecticide) -- Metabolism.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Agricultural Biochemistry and Nutrition; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Stull, J. W.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleMETABOLISM OF 2,2, - BIS (P-CHLOROPHENYL)-1, 1-DICHLOROETHYLENE (DDE) BY THE BOVINE.en_US
dc.creatorMOHAMMAD, KASSIM HASSAN.en_US
dc.contributor.authorMOHAMMAD, KASSIM HASSAN.en_US
dc.date.issued1984en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractTwelve lactating Holstein dairy cows were randomly divided into four groups of three animals each. Group A served as the control, group B was dosed at 0.05ppm/day of DDE (2,2-bis(P-chlorophenyl-1, 1-dichloroethylene), cows in group C were dosed at 0.1ppm DDE/day, while group D cows were dosed at 1.0ppm DDE/day. DDE was administered in a residue free peanut oil solution for 32-consecutive days. Milk samples were taken daily during the 32 day dosing period and for an additional 32 days after the dosing period. Quantitative analysis of DDE residue in milk fat was determined by using a Tracor MT-220 gas chromatograph with a Tritium electron capture detector. The average increase in DDE milk fat concentration during the dosing period was directly related to intake levels. DDE was the only organochlorine compound detected in the milk fat. The general slope and shape of the curves of milk fat DDE levels were similar for all treatments. The levels of DDE increased rapidly after the onset of dosing. After 15 days of dosing and throughout the remaining 17 days of the dosing period, milk fat DDE increased at a relatively slow rate. The level of milk fat DDE declined rapidly as soon as the DDE residue source was withdrawn. At the end of the 32-day post-dosing period, one cow from each group was slaughtered and samples were taken from muscles, brain, lung, lymph, spleen, kidney fat, heart, gonad, placenta, udder, and kidney for DDE analysis. Considerable DDE was found in the muscle, lymph, kidney fat, and udder tissues.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectEthylene compounds -- Metabolism.en_US
dc.subjectPublisher 1984.en_US
dc.subjectMilk contamination.en_US
dc.subjectOrganochlorine compounds -- Metabolism.en_US
dc.subjectDDT (Insecticide) -- Metabolism.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineAgricultural Biochemistry and Nutritionen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorStull, J. W.en_US
dc.identifier.proquest8424909en_US
dc.identifier.oclc691379660en_US
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