Persistent Link:
http://hdl.handle.net/10150/186104
Title:
BEHAVIORAL RESPONSES TO HALDOL AND SINEMET IN SQUIRREL MONKEYS.
Author:
KIRKISH, PATRICIA MARIE.
Issue Date:
1983
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Two dopaminergic altering drugs, haloperidol and carbidopa + levodopa, and juice only conditions, were given to six squirrel monkeys in factorial combination with two novel environments and an alone condition. The point of this research was to assess differences in subjects' adaptation to various stimulus conditions under the differential influence of the two drug conditions. Control conditions for both drug and environmental variables were included in the design, which provided a baseline for comparison with active variables. Although no significant interactions between drugs and environments were found, some interesting reactions to the non-drug-laced vehicle were noted. The drugs, haloperidol and carbidopa-levodopa, have been used in many past comparative studies. However, the thrust of most research has been focused upon changes in movement capability, or deterioration of movement ability. Extrapyramidal side-effects, such as bizarre facial and tongue movement and postural changes, have generally been included in these investigations. Little attention has been placed upon adaptive change to novel environments, which may occur with these drugs. This research represents an initial investigation of such changes, an important consideration in view of their widespread use as therapeutic agents with humans.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Neuropsychiatry.; Neurology.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Psychology; Graduate College
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleBEHAVIORAL RESPONSES TO HALDOL AND SINEMET IN SQUIRREL MONKEYS.en_US
dc.creatorKIRKISH, PATRICIA MARIE.en_US
dc.contributor.authorKIRKISH, PATRICIA MARIE.en_US
dc.date.issued1983en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractTwo dopaminergic altering drugs, haloperidol and carbidopa + levodopa, and juice only conditions, were given to six squirrel monkeys in factorial combination with two novel environments and an alone condition. The point of this research was to assess differences in subjects' adaptation to various stimulus conditions under the differential influence of the two drug conditions. Control conditions for both drug and environmental variables were included in the design, which provided a baseline for comparison with active variables. Although no significant interactions between drugs and environments were found, some interesting reactions to the non-drug-laced vehicle were noted. The drugs, haloperidol and carbidopa-levodopa, have been used in many past comparative studies. However, the thrust of most research has been focused upon changes in movement capability, or deterioration of movement ability. Extrapyramidal side-effects, such as bizarre facial and tongue movement and postural changes, have generally been included in these investigations. Little attention has been placed upon adaptive change to novel environments, which may occur with these drugs. This research represents an initial investigation of such changes, an important consideration in view of their widespread use as therapeutic agents with humans.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectNeuropsychiatry.en_US
dc.subjectNeurology.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplinePsychologyen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.identifier.proquest8315290en_US
dc.identifier.oclc688637660en_US
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