Direct ovarian steroid regulation of pituitary luteinizing hormone secretion, stores and subunit mRNA.

Persistent Link:
http://hdl.handle.net/10150/185816
Title:
Direct ovarian steroid regulation of pituitary luteinizing hormone secretion, stores and subunit mRNA.
Author:
Girmus, Ronald Leslie
Issue Date:
1992
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The ovarian steroids, progesterone and estradiol, regulate luteinizing hormone synthesis and secretion during the estrous cycle of mature ewes. During the luteal phase of the cycle the ovarian steroids inhibit luteinizing hormone secretion. Luteinizing hormone is secreted from the pituitary when stimulated by the hypothalamic neuropeptide, gonadotropin-releasing hormone. Ovarian steroids can inhibit luteinizing hormone secretion indirectly, by decreasing the secretion of gonadotropin-releasing hormone or directly, by modulating the response of the pituitary to gonadotropin-releasing hormone. These studies have examined the direct control of pituitary luteinizing hormone secretion by using an in vivo model in which endogenous gonadotropin-releasing hormone (GnRH) release has been ablated and replaced with exogenous GnRH release at a constant frequency. Progesterone directly inhibited pituitary LH secretion in an estradiol-dependent manner and this may not require inhibition of pituitary LH synthesis. Progesterone inhibition of pituitary luteinizing hormone secretion is associated with enhanced progesterone binding by the pituitary.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Dissertations, Academic.; Neurosciences.; Gynecology.; Luteinizing hormone releasing hormone.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Animal Physiology; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Wise, Mark E.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleDirect ovarian steroid regulation of pituitary luteinizing hormone secretion, stores and subunit mRNA.en_US
dc.creatorGirmus, Ronald Leslieen_US
dc.contributor.authorGirmus, Ronald Leslieen_US
dc.date.issued1992en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe ovarian steroids, progesterone and estradiol, regulate luteinizing hormone synthesis and secretion during the estrous cycle of mature ewes. During the luteal phase of the cycle the ovarian steroids inhibit luteinizing hormone secretion. Luteinizing hormone is secreted from the pituitary when stimulated by the hypothalamic neuropeptide, gonadotropin-releasing hormone. Ovarian steroids can inhibit luteinizing hormone secretion indirectly, by decreasing the secretion of gonadotropin-releasing hormone or directly, by modulating the response of the pituitary to gonadotropin-releasing hormone. These studies have examined the direct control of pituitary luteinizing hormone secretion by using an in vivo model in which endogenous gonadotropin-releasing hormone (GnRH) release has been ablated and replaced with exogenous GnRH release at a constant frequency. Progesterone directly inhibited pituitary LH secretion in an estradiol-dependent manner and this may not require inhibition of pituitary LH synthesis. Progesterone inhibition of pituitary luteinizing hormone secretion is associated with enhanced progesterone binding by the pituitary.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectDissertations, Academic.en_US
dc.subjectNeurosciences.en_US
dc.subjectGynecology.en_US
dc.subjectLuteinizing hormone releasing hormone.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineAnimal Physiologyen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorWise, Mark E.en_US
dc.contributor.committeememberAllen, Ronald E.en_US
dc.contributor.committeememberKomm, Barry S.en_US
dc.contributor.committeememberGuerriero, Vincenten_US
dc.contributor.committeememberHoyer, Patricia B.en_US
dc.identifier.proquest9225177en_US
dc.identifier.oclc712649002en_US
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