INFLUENCE OF CYCLOPHOSPHAMIDE ON THE RESPONSE OF MICE TO BOVINE AND PORCINE TRANSFER FACTOR.

Persistent Link:
http://hdl.handle.net/10150/185282
Title:
INFLUENCE OF CYCLOPHOSPHAMIDE ON THE RESPONSE OF MICE TO BOVINE AND PORCINE TRANSFER FACTOR.
Author:
CLARK, PAUL DOUGLAS.
Issue Date:
1982
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Cyclophosphamide (CY) was injected intraperitoneally into mice at varying dosage levels 48 hours prior to intravenous inoculation of constant amounts of dialysable leucocytic transfer factor (TF). Bovine TF to coccidioidin and Brucella abortus and porcine TF to Mycobacterium avium were used. Twenty-four hours after TF injections, mice were tested for delayed hypersensitivity by footpad inoculation with specific antigens. The results show that CY slightly enhanced the delayed hypersensitivity response to the specific test antigens in all three systems. This was not true at every CY dose level, however, since there was a correlation between the dosage of CY and the time of peak footpad swelling. Cyclophosphamide at a low level (20 mg/kg body wt) caused the maximal reading at 24 hours after test, whereas the high level dose (200 mg/kg) showed greatest thickening of the footpad at 48 hours. Transfer factor dosage differences appeared to change the response relatively little, if at all. The cyclophosphamide dose response, on the other hand, showed disparities among various antigen systems and at the different observation times. Under these conditions, no consistent, striking effects of CY on transfer could be noted.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Transfer factor (Immunology); Immune response.; Cyclophosphamide.; Mice as laboratory animals.; Immunosuppressive agents.
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Chemistry; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Wilson, George S.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleINFLUENCE OF CYCLOPHOSPHAMIDE ON THE RESPONSE OF MICE TO BOVINE AND PORCINE TRANSFER FACTOR.en_US
dc.creatorCLARK, PAUL DOUGLAS.en_US
dc.contributor.authorCLARK, PAUL DOUGLAS.en_US
dc.date.issued1982en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractCyclophosphamide (CY) was injected intraperitoneally into mice at varying dosage levels 48 hours prior to intravenous inoculation of constant amounts of dialysable leucocytic transfer factor (TF). Bovine TF to coccidioidin and Brucella abortus and porcine TF to Mycobacterium avium were used. Twenty-four hours after TF injections, mice were tested for delayed hypersensitivity by footpad inoculation with specific antigens. The results show that CY slightly enhanced the delayed hypersensitivity response to the specific test antigens in all three systems. This was not true at every CY dose level, however, since there was a correlation between the dosage of CY and the time of peak footpad swelling. Cyclophosphamide at a low level (20 mg/kg body wt) caused the maximal reading at 24 hours after test, whereas the high level dose (200 mg/kg) showed greatest thickening of the footpad at 48 hours. Transfer factor dosage differences appeared to change the response relatively little, if at all. The cyclophosphamide dose response, on the other hand, showed disparities among various antigen systems and at the different observation times. Under these conditions, no consistent, striking effects of CY on transfer could be noted.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectTransfer factor (Immunology)en_US
dc.subjectImmune response.en_US
dc.subjectCyclophosphamide.en_US
dc.subjectMice as laboratory animals.en_US
dc.subjectImmunosuppressive agents.en_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorWilson, George S.en_US
dc.identifier.proquest8306451en_US
dc.identifier.oclc688242080en_US
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