The effects of arginine/lysine supplementation and resistance training on glucose tolerance and glomerular filtration rate: Relationship with alterations in selected hormonal parameters.

Persistent Link:
http://hdl.handle.net/10150/185105
Title:
The effects of arginine/lysine supplementation and resistance training on glucose tolerance and glomerular filtration rate: Relationship with alterations in selected hormonal parameters.
Author:
Gater, David Rex, Jr.
Issue Date:
1990
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
The purposes of this study were to evaluate and compare the independent and combined effects of arginine/lysine (AL) supplementation and resistance training (RT) on glucose tolerance and golmerular filtration rate, and to determine whether or not alterations were associated with changes in selected hormonal parameters. The study involved 30 physically active college males, ages 20-30 years, randomly assigned to one of four groups: Placebo/Control (P/C, n = 7), P/RT (n = 8), AL/C (n = 7), or AL/RT (n = 8). During the 10-week program, exercise subjects participated in a progressive resistance training program stressing all major muscle groups. An arginine/lysine supplement at a dosage of 132 mg/kg fat-free body (FFB) or placebo was administered to controls and training groups. Oral glucose tolerance (OGT) tests were performed on each subject before and after the 10-week intervention in order to evaluate resting levels of plasma insulin-like growth factor-1 (IGF-1), as well as resting levels and responses of glucose, insulin and glucagon for 180 minutes following an oral glucose challenge. Glomerular filtration rate (GFR) was determined from creatinine clearance (C(Cr)) as calculated from plasma creatinine, urine creatinine and urine flow. Significant increases in strength, and fat-free body (FFB) weight were seen in both resistance trained groups compared to controls, while supplement status had no apparent effect. Glucose tolerance parameters which significantly increased following the 10-week intervention included resting insulin for P/RT and glucagon area under the curve (AUC) for P/C, AL/C, and P/RT. While IGF-1 did not significantly increase within groups, a significant post-treatment difference was seen between P/RT (0.93 ± 0.10 U/ml) and AL/RT (0.60 ± 0.08 u/ml); percent carbohydrate in diet and absolute change in FFB were significant predictors of the absolute change in IGF-1, accounting for 22.0% (p < 0.01) and 20.8% (p < 0.01) of the variability, respectively. It was concluded that AL supplementation for 10 weeks had no significant effect on strength, FFB, OGT or GFR, while RT increased both strength and FFB with no significant effect on OGT or GFR.
Type:
text; Dissertation-Reproduction (electronic)
Keywords:
Biology
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Physiology; Graduate College
Degree Grantor:
University of Arizona
Advisor:
Hoyer, Patricia B.

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleThe effects of arginine/lysine supplementation and resistance training on glucose tolerance and glomerular filtration rate: Relationship with alterations in selected hormonal parameters.en_US
dc.creatorGater, David Rex, Jr.en_US
dc.contributor.authorGater, David Rex, Jr.en_US
dc.date.issued1990en_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractThe purposes of this study were to evaluate and compare the independent and combined effects of arginine/lysine (AL) supplementation and resistance training (RT) on glucose tolerance and golmerular filtration rate, and to determine whether or not alterations were associated with changes in selected hormonal parameters. The study involved 30 physically active college males, ages 20-30 years, randomly assigned to one of four groups: Placebo/Control (P/C, n = 7), P/RT (n = 8), AL/C (n = 7), or AL/RT (n = 8). During the 10-week program, exercise subjects participated in a progressive resistance training program stressing all major muscle groups. An arginine/lysine supplement at a dosage of 132 mg/kg fat-free body (FFB) or placebo was administered to controls and training groups. Oral glucose tolerance (OGT) tests were performed on each subject before and after the 10-week intervention in order to evaluate resting levels of plasma insulin-like growth factor-1 (IGF-1), as well as resting levels and responses of glucose, insulin and glucagon for 180 minutes following an oral glucose challenge. Glomerular filtration rate (GFR) was determined from creatinine clearance (C(Cr)) as calculated from plasma creatinine, urine creatinine and urine flow. Significant increases in strength, and fat-free body (FFB) weight were seen in both resistance trained groups compared to controls, while supplement status had no apparent effect. Glucose tolerance parameters which significantly increased following the 10-week intervention included resting insulin for P/RT and glucagon area under the curve (AUC) for P/C, AL/C, and P/RT. While IGF-1 did not significantly increase within groups, a significant post-treatment difference was seen between P/RT (0.93 ± 0.10 U/ml) and AL/RT (0.60 ± 0.08 u/ml); percent carbohydrate in diet and absolute change in FFB were significant predictors of the absolute change in IGF-1, accounting for 22.0% (p < 0.01) and 20.8% (p < 0.01) of the variability, respectively. It was concluded that AL supplementation for 10 weeks had no significant effect on strength, FFB, OGT or GFR, while RT increased both strength and FFB with no significant effect on OGT or GFR.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.subjectBiologyen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplinePhysiologyen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorHoyer, Patricia B.en_US
dc.contributor.committeememberBunt, Joy C.en_US
dc.identifier.proquest9032528en_US
dc.identifier.oclc708376695en_US
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