Data Summary: Significance of Family History in Breast Cancer Diagnosis

Persistent Link:
http://hdl.handle.net/10150/146566
Title:
Data Summary: Significance of Family History in Breast Cancer Diagnosis
Author:
Garcia, Mary Carmen
Issue Date:
May-2010
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Background: Family history and its significance in Hispanic breast cancer cases with a known BRCA mutation has not been widely studied. Methods: Family history, BRCA mutation and age data were obtained for a subset of 91 individuals derived from the ELLA Binational Breast Cancer Study population, in order to determine the importance of family history in the context of BRCA mutation status. Results: A total of 8 different BRCA1 and BRCA2 mutations were found within the study population. Only 11 of the 91 participants (12.1%) were found to possess a BRCA mutation. Of these 11 women, 6 (54.5%) had a positive family history of cancer. This is greater than the expected percentage (23.5%) reported in the literature. Conclusion: Over half of those individuals that were found to have a BRCA mutation also had a positive family history of cancer. Therefore, family history is an important component when assessing breast cancer risk in populations of Hispanic women but can often be obscured due to limited family structure. Family history could be evaluated more effectively in the ELLA Study through the use of a modified questionnaire that probes for family structure.
Type:
text; Electronic Thesis
Degree Name:
B.S.
Degree Level:
bachelors
Degree Program:
Honors College; Physiology
Degree Grantor:
University of Arizona

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleData Summary: Significance of Family History in Breast Cancer Diagnosisen_US
dc.creatorGarcia, Mary Carmenen_US
dc.contributor.authorGarcia, Mary Carmenen_US
dc.date.issued2010-05-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractBackground: Family history and its significance in Hispanic breast cancer cases with a known BRCA mutation has not been widely studied. Methods: Family history, BRCA mutation and age data were obtained for a subset of 91 individuals derived from the ELLA Binational Breast Cancer Study population, in order to determine the importance of family history in the context of BRCA mutation status. Results: A total of 8 different BRCA1 and BRCA2 mutations were found within the study population. Only 11 of the 91 participants (12.1%) were found to possess a BRCA mutation. Of these 11 women, 6 (54.5%) had a positive family history of cancer. This is greater than the expected percentage (23.5%) reported in the literature. Conclusion: Over half of those individuals that were found to have a BRCA mutation also had a positive family history of cancer. Therefore, family history is an important component when assessing breast cancer risk in populations of Hispanic women but can often be obscured due to limited family structure. Family history could be evaluated more effectively in the ELLA Study through the use of a modified questionnaire that probes for family structure.en_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.nameB.S.en_US
thesis.degree.levelbachelorsen_US
thesis.degree.disciplineHonors Collegeen_US
thesis.degree.disciplinePhysiologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
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