High-Resolution Gamma-Ray Imaging with Columnar Scintillators and CCD/CMOS Sensors, and FastSPECT III: A Third-Generation Stationary SPECT Imager

Persistent Link:
http://hdl.handle.net/10150/145424
Title:
High-Resolution Gamma-Ray Imaging with Columnar Scintillators and CCD/CMOS Sensors, and FastSPECT III: A Third-Generation Stationary SPECT Imager
Author:
Miller, Brian William
Issue Date:
2011
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
A new class of scintillation detector has emerged that combines columnar scintillators and CCD/CMOS sensors for high-resolution imaging. Originally developed for single-photon gamma-ray imaging, these detectors provide better than an order-of-magnitude improvement in spatial resolution compared to conventional photomultiplier tube (PMT)-based gamma cameras; sub-100 micron detector resolutions have been achieved. This work reviews the several detector configurations developed in recent years, with a specific emphasis on a type of CCD/CMOS detector developed at the Center for Gamma-Ray Imaging, which we call BazookaSPECT, that amplifies scintillation light using an image intensifier to achieve both high spatial resolution and high event-rate capability.Ongoing research into scintillator deposition techniques has led to a new form of scintillation material where crystallites are organized into columns. Similar to optical fibers, this columnar structure helps to channels scintillation light towards an exit face while restricting lateral light spread. However, because they are not perfect optical fibers, light spreads laterally and is absorbed by an amount relating to the interaction depth. Taking advantage of this phenomenon, we discuss the use of maximum-likelihood methods to estimate the 3D position and energy of gamma-ray interactions in columnar CsI(Tl)/EMCCD-based detectors.Finally, we present new imaging applications that have arisen from BazookaSPECT. These include the the development of a gamma-ray microscope using micro-coded apertures, feasibility studies for photon-counting digital mammography and eventually X-ray CT, and FastSPECT III -- a third generation small animal stationary SPECT imager. FastSPECT III system design, fabrication methods, data acquisition system, system calibration procedure, and initial tomographic reconstructions are presented.
Type:
Electronic Dissertation; text
Keywords:
BazookaSPECT; columnar scintillators; FastSPECT; gamma-ray imaging; SPECT; stationary SPECT
Degree Name:
Ph.D.
Degree Level:
doctoral
Degree Program:
Graduate College; Optical Sciences
Degree Grantor:
University of Arizona
Advisor:
Furenlid, Lars R; Barrett, Harrison H

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleHigh-Resolution Gamma-Ray Imaging with Columnar Scintillators and CCD/CMOS Sensors, and FastSPECT III: A Third-Generation Stationary SPECT Imageren_US
dc.creatorMiller, Brian Williamen_US
dc.contributor.authorMiller, Brian Williamen_US
dc.date.issued2011-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractA new class of scintillation detector has emerged that combines columnar scintillators and CCD/CMOS sensors for high-resolution imaging. Originally developed for single-photon gamma-ray imaging, these detectors provide better than an order-of-magnitude improvement in spatial resolution compared to conventional photomultiplier tube (PMT)-based gamma cameras; sub-100 micron detector resolutions have been achieved. This work reviews the several detector configurations developed in recent years, with a specific emphasis on a type of CCD/CMOS detector developed at the Center for Gamma-Ray Imaging, which we call BazookaSPECT, that amplifies scintillation light using an image intensifier to achieve both high spatial resolution and high event-rate capability.Ongoing research into scintillator deposition techniques has led to a new form of scintillation material where crystallites are organized into columns. Similar to optical fibers, this columnar structure helps to channels scintillation light towards an exit face while restricting lateral light spread. However, because they are not perfect optical fibers, light spreads laterally and is absorbed by an amount relating to the interaction depth. Taking advantage of this phenomenon, we discuss the use of maximum-likelihood methods to estimate the 3D position and energy of gamma-ray interactions in columnar CsI(Tl)/EMCCD-based detectors.Finally, we present new imaging applications that have arisen from BazookaSPECT. These include the the development of a gamma-ray microscope using micro-coded apertures, feasibility studies for photon-counting digital mammography and eventually X-ray CT, and FastSPECT III -- a third generation small animal stationary SPECT imager. FastSPECT III system design, fabrication methods, data acquisition system, system calibration procedure, and initial tomographic reconstructions are presented.en_US
dc.typeElectronic Dissertationen_US
dc.typetexten_US
dc.subjectBazookaSPECTen_US
dc.subjectcolumnar scintillatorsen_US
dc.subjectFastSPECTen_US
dc.subjectgamma-ray imagingen_US
dc.subjectSPECTen_US
dc.subjectstationary SPECTen_US
thesis.degree.namePh.D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineOptical Sciencesen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorFurenlid, Lars Ren_US
dc.contributor.advisorBarrett, Harrison Hen_US
dc.contributor.committeememberTrouard, Theodoreen_US
dc.contributor.committeememberBarber, H. Bradforden_US
dc.identifier.proquest11551-
dc.identifier.oclc752261414-
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