Toward a Method for Biomechanical Determination of Aneurysm Progression in Mouse Models

Persistent Link:
http://hdl.handle.net/10150/144598
Title:
Toward a Method for Biomechanical Determination of Aneurysm Progression in Mouse Models
Author:
Haskett, Darren
Issue Date:
2011
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Aortic aneurysm is a complex disease manifesting in a localized dilation of the aorta developing over years and carries with it a significant chance of rupture resulting in death. As only surgical methods are currently available for treatment, there is a need to understand the underlying mechanisms of the disease and how they develop and lead to expansion and rupture. Thus, the study of the formation and progression of aneurysm has also focused on quantifying any changes observed in fiber realignment and altered mechanical properties leading to vascular disease. Animal models of aneurismal disease can be useful for studying alterations during disease development (e.g., in the tissue's mechanical response). Recent efforts have been aimed at determining both the biomechanical alterations that occur with aneurysm formation and their potential for rupture. However, previous animal model work is lacking quantitative descriptions of how biomechanical response and vessel remodeling change with time and lead to the diseased state. Thus, there is a need for determining an appropriate animal model for aneurysm and developing an adequate method for quantifying and determining disease progression through alterations in biomechanical response.
Type:
Electronic Thesis; text
Keywords:
Aneurysm; AngII; Animal Models; aortac; biomechanical; Fib1
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Biomedical Engineering
Degree Grantor:
University of Arizona
Advisor:
Vande Geest, Jonathan P

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titleToward a Method for Biomechanical Determination of Aneurysm Progression in Mouse Modelsen_US
dc.creatorHaskett, Darrenen_US
dc.contributor.authorHaskett, Darrenen_US
dc.date.issued2011-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractAortic aneurysm is a complex disease manifesting in a localized dilation of the aorta developing over years and carries with it a significant chance of rupture resulting in death. As only surgical methods are currently available for treatment, there is a need to understand the underlying mechanisms of the disease and how they develop and lead to expansion and rupture. Thus, the study of the formation and progression of aneurysm has also focused on quantifying any changes observed in fiber realignment and altered mechanical properties leading to vascular disease. Animal models of aneurismal disease can be useful for studying alterations during disease development (e.g., in the tissue's mechanical response). Recent efforts have been aimed at determining both the biomechanical alterations that occur with aneurysm formation and their potential for rupture. However, previous animal model work is lacking quantitative descriptions of how biomechanical response and vessel remodeling change with time and lead to the diseased state. Thus, there is a need for determining an appropriate animal model for aneurysm and developing an adequate method for quantifying and determining disease progression through alterations in biomechanical response.en_US
dc.typeElectronic Thesisen_US
dc.typetexten_US
dc.subjectAneurysmen_US
dc.subjectAngIIen_US
dc.subjectAnimal Modelsen_US
dc.subjectaortacen_US
dc.subjectbiomechanicalen_US
dc.subjectFib1en_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineBiomedical Engineeringen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorVande Geest, Jonathan Pen_US
dc.contributor.committeememberAzhar, Mohamaden_US
dc.contributor.committeememberWu, Xiaoyien_US
dc.contributor.committeememberUtzinger, Ursen_US
dc.identifier.proquest11617-
dc.identifier.oclc752261475-
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