Persistent Link:
http://hdl.handle.net/10150/144593
Title:
Pregnancy and its association with breast cancer tumor subtypes
Author:
Cruz, Giovanna Ibeth
Issue Date:
2011
Publisher:
The University of Arizona.
Rights:
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Abstract:
Parity is associated with a short–term increase in breast cancer (BC) risk followed by a long–term decrease in risk. BC diagnosed 5–7 years after a completed pregnancy is associated with worse outcomes. BC is not a single disease. The dual effect of pregnancy could account for the BC characteristics at presentation (i.e. younger age and more advanced disease) and worse outcomes observed among Hispanics, relative to Non–Hispanic Whites. The purpose of this study was to investigate the association of reproductive characteristics by tumor subtype in a case series of women of Mexican–descent. Cases diagnosed ≤10 years following a birth had nearly 3 times the odds of a diagnosis with HER2+ tumors, relative to ER+/PR+ tumors. HER2+ tumors are associated with reduced survival compared to ER+/PR+ tumors. Diagnosis within a recent pregnancy may contribute to the aggressiveness of BC observed among women of Mexican descent ≤50 years of age.
Type:
Electronic Thesis; text
Keywords:
epidemiology; breast cancer; Hispanics; pregnancy; reproductive factors; tumor subtypes
Degree Name:
M.S.
Degree Level:
masters
Degree Program:
Graduate College; Epidemiology
Degree Grantor:
University of Arizona
Advisor:
Martinez, Maria E

Full metadata record

DC FieldValue Language
dc.language.isoenen_US
dc.titlePregnancy and its association with breast cancer tumor subtypesen_US
dc.creatorCruz, Giovanna Ibethen_US
dc.contributor.authorCruz, Giovanna Ibethen_US
dc.date.issued2011-
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.description.abstractParity is associated with a short–term increase in breast cancer (BC) risk followed by a long–term decrease in risk. BC diagnosed 5–7 years after a completed pregnancy is associated with worse outcomes. BC is not a single disease. The dual effect of pregnancy could account for the BC characteristics at presentation (i.e. younger age and more advanced disease) and worse outcomes observed among Hispanics, relative to Non–Hispanic Whites. The purpose of this study was to investigate the association of reproductive characteristics by tumor subtype in a case series of women of Mexican–descent. Cases diagnosed ≤10 years following a birth had nearly 3 times the odds of a diagnosis with HER2+ tumors, relative to ER+/PR+ tumors. HER2+ tumors are associated with reduced survival compared to ER+/PR+ tumors. Diagnosis within a recent pregnancy may contribute to the aggressiveness of BC observed among women of Mexican descent ≤50 years of age.en_US
dc.typeElectronic Thesisen_US
dc.typetexten_US
dc.subjectepidemiologyen_US
dc.subjectbreast canceren_US
dc.subjectHispanicsen_US
dc.subjectpregnancyen_US
dc.subjectreproductive factorsen_US
dc.subjecttumor subtypesen_US
thesis.degree.nameM.S.en_US
thesis.degree.levelmastersen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineEpidemiologyen_US
thesis.degree.grantorUniversity of Arizonaen_US
dc.contributor.advisorMartinez, Maria Een_US
dc.contributor.committeememberSherrill, Duaneen_US
dc.contributor.committeememberThompson, Patriciaen_US
dc.identifier.proquest11610-
dc.identifier.oclc752261469-
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